Noncoding RNAs in skeletal development and disorders

Yao，Qing1; He，Tailin1; Liao，Jian You2,3; Liao，Rongdong1,4; Wu，Xiaohao1; Lin，Lijun4; Xiao，Guozhi1

2024-12-01

10.1186/s40659-024-00497-y

Biological Research   影响因子和分区

0716-9760

0717-6287

Protein-encoding genes only constitute less than 2% of total human genomic sequences, and 98% of genetic information was previously referred to as “junk DNA”. Meanwhile, non-coding RNAs (ncRNAs) consist of approximately 60% of the transcriptional output of human cells. Thousands of ncRNAs have been identified in recent decades, and their essential roles in the regulation of gene expression in diverse cellular pathways associated with fundamental cell processes, including proliferation, differentiation, apoptosis, and metabolism, have been extensively investigated. Furthermore, the gene regulation networks they form modulate gene expression in normal development and under pathological conditions. In this review, we integrate current information about the classification, biogenesis, and function of ncRNAs and how these ncRNAs support skeletal development through their regulation of critical genes and signaling pathways in vivo. We also summarize the updated knowledge of ncRNAs involved in common skeletal diseases and disorders, including but not limited to osteoporosis, osteoarthritis, rheumatoid arthritis, scoliosis, and intervertebral disc degeneration, by highlighting their roles established from in vivo, in vitro, and ex vivo studies.

SCI

英语

第一 ; 通讯

BIOLOGY & BIOCHEMISTRY

2-s2.0-85190858783

Scopus

1.Department of Biochemistry,School of Medicine,Shenzhen Key Laboratory of Cell Microenvironment,Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research,Southern University of Science and Technology,Shenzhen,518055,China
2.Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation,Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University,Guangzhou,510120,China
3.Medical Research Center,Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University,Guangzhou,510120,China
4.Department of Orthopedics,Zhujiang Hospital,Southern Medical University,Guangzhou,510280,China

Yao，Qing,He，Tailin,Liao，Jian You,et al. Noncoding RNAs in skeletal development and disorders[J]. Biological Research,2024,57(1).

Yao，Qing.,He，Tailin.,Liao，Jian You.,Liao，Rongdong.,Wu，Xiaohao.,...&Xiao，Guozhi.(2024).Noncoding RNAs in skeletal development and disorders.Biological Research,57(1).

Yao，Qing,et al."Noncoding RNAs in skeletal development and disorders".Biological Research 57.1(2024).