A tantalum-containing zirconium-based metallic glass with superior endosseous implant relevant properties

Wu，Yunshu1,2,3,4; Wang，Feifei1,2,3; Huang，Yao5; Zheng，Fu2,3,6; Zeng，Yuhao1,2,3; Lu，Zhen5; Wang，Songlin4,7; Sun，Baoan5; Sun，Yuchun1,2,3

2024-09-01

10.1016/j.bioactmat.2024.04.014

Bioactive Materials   影响因子和分区

2452-199X

Zirconium-based metallic glasses (Zr-MGs) are demonstrated to exhibit high mechanical strength, low elastic modulus and excellent biocompatibility, making them promising materials for endosseous implants. Meanwhile, tantalum (Ta) is also well known for its ideal corrosion resistance and biological effects. However, the metal has an elastic modulus as high as 186 GPa which is not comparable to the natural bone (10–30 GPa), and it also has a relative high cost. Here, to fully exploit the advantages of Ta as endosseous implants, a small amount of Ta (as low as 3 at. %) was successfully added into a Zr-MG to generate an advanced functional endosseous implant, ZrCuAlTa MG, with superior comprehensive properties. Upon carefully dissecting the atomic structure and surface chemistry, the results show that amorphization of Ta enables the uniform distribution in material surface, leading to a significantly improved chemical stability and extensive material-cell contact regulation. Systematical analyses on the immunological, angiogenesis and osteogenesis capability of the material are carried out utilizing the next-generation sequencing, revealing that ZrCuAlTa MG can regulate angiogenesis through VEGF signaling pathway and osteogenesis via BMP signaling pathway. Animal experiment further confirms a sound osseointegration of ZrCuAlTa MG in achieving better bone-implant-contact and inducing faster peri-implant bone formation.

Atomic structure Endosseous implant Surface chemistry Tantalum Zirconium-based metallic glass

SCI

英语

其他

2-s2.0-85192698515

Scopus

1.Center of Digital Dentistry,Peking University School and Hospital of Stomatology,Beijing,100081,China
2.National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices,Beijing,100081,China
3.Beijing Key Laboratory of Digital Stomatology,Beijing,100081,China
4.Beijing Laboratory of Oral Health,Capital Medical University,Beijing,100069,China
5.Institute of Physics,Chinese Academy of Sciences,Beijing,100190,China
6.Department of Orthodontics,Peking University School and Hospital of Stomatology,Beijing,100081,China
7.Laboratory of Homeostatic Medicine,School of Medicine,Southern University of Science and Technology,Shenzhen,518055,China

Wu，Yunshu,Wang，Feifei,Huang，Yao,et al. A tantalum-containing zirconium-based metallic glass with superior endosseous implant relevant properties[J]. Bioactive Materials,2024,39:25-40.

Wu，Yunshu.,Wang，Feifei.,Huang，Yao.,Zheng，Fu.,Zeng，Yuhao.,...&Sun，Yuchun.(2024).A tantalum-containing zirconium-based metallic glass with superior endosseous implant relevant properties.Bioactive Materials,39,25-40.

Wu，Yunshu,et al."A tantalum-containing zirconium-based metallic glass with superior endosseous implant relevant properties".Bioactive Materials 39(2024):25-40.