Association between the stress–hyperglycemia ratio and all-cause mortality in community-dwelling populations: An analysis of the National Health and Nutrition Examination Survey (NHANES) 1999–2014

Qiu，Shifeng1,2,3; Liu，Xiaocong1,2,3; Lei，Li4; Liang，Hongbin1,2,3; Li，Xue5; Wang，Yutian1,2,3; Yu，Chen1,2,3; Li，Xiaobo6; Tang，Yongzhen1,2,3; Wu，Juefei1,2,3; Wang，Yuegang1,2,3; Zha，Daogang1,2,3,7; Liu，Xuewei2,8; Xiao，Min1,2,3; Xiu，Jiancheng1,2,3

2024-06-01

10.1111/1753-0407.13567

Journal of Diabetes   影响因子和分区

1753-0393

1753-0407

Background: Reportedly, the stress–hyperglycemia ratio (SHR) is closely associated with poor prognosis in patients with severe acute disease. However, the community-dwelling may also be in a state of stress due to environmental exposure. Our study aimed to explore the association between SHR and all-cause mortality in the community-dwelling population. Methods: A total of 18 480 participants were included out of 82 091 from the NHANES 1999–2014 survey. The Kaplan–Meier survival analyses were used to assess the disparities in survival rates based on SHR, and the log-rank test was employed to investigate the distinctions between groups. The multivariate Cox regression analysis and restricted cubic spline (RCS) analysis were performed to assess the association of SHR with all-cause mortality. A subgroup analysis was also conducted. Results: A total of 3188 deaths occurred during a median follow-up period of 11.0 (7.7; 15.4) years. The highest risk for all-cause mortality was observed when SHR≤ 0.843 or SHR ≥0.986 (log-rank p <.001). After adjusting for the confounding factors, compared with subjects in the second SHR quartile (Q2), participants in the highest (Q4, adjusted hazard ratio [HR] 1.49, 95% confidence interval [CI] 1.28–1.73) and lowest quartiles (Q1, adjusted HR 1.37, 95% CI 1.16–1.60) have a higher probability of all-cause death. The RCS observed a dose-response U-shaped association between SHR and all-cause mortality. The U-shaped association between SHR and all-cause mortality was similar across subgroup analysis. Conclusions: The SHR was significantly associated with all-cause mortality in the community-dwelling population, and the relationship was U-shaped. (Figure presented.).

all-cause mortality community-dwelling NHANES stress–hyperglycemia ratio U-shaped

SCI

英语

其他

2-s2.0-85193724609

Scopus

1.Department of Cardiology,Nanfang Hospital,Southern Medical University,Guangzhou,China
2.Guangdong Provincial Key Laboratory of Shock and Microcirculation,Nanfang Hospital,Southern Medical University,Guangzhou,China
3.State Key Laboratory of Organ Failure Research,Nanfang Hospital,Southern Medical University,Guangzhou,China
4.Department of Cardiology,Shenzhen People's Hospital (The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,China
5.Department of Gastroenterology,Nanfang Hospital,Southern Medical University,Guangzhou,China
6.Department of Cardiology,Xiangdong Hospital Affiliated to Hunan Normal University,Zhuzhou,China
7.Department of General Practice,Nanfang Hospital,Southern Medical University,Guangzhou,China
8.The First School of Clinical Medicine,Southern Medical University,Dongguan,China

Qiu，Shifeng,Liu，Xiaocong,Lei，Li,等. Association between the stress–hyperglycemia ratio and all-cause mortality in community-dwelling populations: An analysis of the National Health and Nutrition Examination Survey (NHANES) 1999–2014[J]. Journal of Diabetes,2024,16(6).

Qiu，Shifeng.,Liu，Xiaocong.,Lei，Li.,Liang，Hongbin.,Li，Xue.,...&Xiu，Jiancheng.(2024).Association between the stress–hyperglycemia ratio and all-cause mortality in community-dwelling populations: An analysis of the National Health and Nutrition Examination Survey (NHANES) 1999–2014.Journal of Diabetes,16(6).

Qiu，Shifeng,et al."Association between the stress–hyperglycemia ratio and all-cause mortality in community-dwelling populations: An analysis of the National Health and Nutrition Examination Survey (NHANES) 1999–2014".Journal of Diabetes 16.6(2024).