A superabsorbent and pH-responsive copolymer-hydrogel based on acemannan from Aloe vera (Aloe barbadensis M.): A smart material for drug delivery

Irfan，Jaffar1; Ali，Arshad1; Hussain，Muhammad Ajaz2; Haseeb，Muhammad Tahir3; Alsahli，Tariq G.4; Naeem-ul-Hassan，Muhammad1; Tulain，Ume Ruqia3; Hussain，Syed Zajif5; Hussain，Irshad5; Azhar，Irfan6

2024-06-01

10.1016/j.ijbiomac.2024.132306

International Journal of Biological Macromolecules   影响因子和分区

0141-8130

1879-0003

Combining natural polysaccharides with synthetic materials improves their functional properties which are essential for designing sustained-release drug delivery systems. In this context, the Aloe vera leaf mucilage/hydrogel (ALH) was reacted with acrylic acid (AA) to synthesize a copolymerized hydrogel, i.e., ALH-grafted-Polyacrylic acid (ALH-g-PAA) through free radical copolymerization. Concentrations of the crosslinker N,N′-methylene-bis-acrylamide (MBA), and the initiator potassium persulfate (KPS) were optimized to study their effects on ALH-g-PAA swelling. The FTIR and solid-state NMR (CP/MAS C NMR) spectra witnessed the formation of ALH-g-PAA. Scanning electron microscopy (SEM) analysis revealed superporous nature of ALH-g-PAA. The gel fraction (%) of ALH-g-PAA was directly related to the concentrations of AA and MBA whereas the sol fraction was inversely related to the concentrations of AA and MBA. The porosity (%) of ALH-g-PAA directly depends on the concentration of AA and MBA. The ALH-g-PAA swelled admirably at pH 7.4 and insignificantly at pH 1.2. The ALH-g-PAA offered on/off switching properties at pH 7.4/1.2. The metoprolol tartrate was loaded on different formulations of ALH-g-PAA. The ALH-g-PAA showed pH, time, and swelling-dependent release of metoprolol tartrate (MT) for 24 h following the first-order kinetic and Korsmeyer-Peppas model. Haemocompatibility studies ascertained the non-thrombogenic and non-hemolytic behavior of ALH-g-PAA.

Acrylic acid Aloe vera hydrogel Copolymerization First-order kinetics On/off switching Porosity

SCI ; EI

英语

其他

BIOLOGY & BIOCHEMISTRY

2-s2.0-85193219690

Scopus

1.Institute of Chemistry,University of Sargodha,Sargodha,40100,Pakistan
2.Centre for Organic Chemistry,School of Chemistry,University of the Punjab,Lahore,54590,Pakistan
3.College of Pharmacy,University of Sargodha,Sargodha,40100,Pakistan
4.Department of Pharmacology,College of Pharmacy,Jouf University,Sakaka,Aljouf,72341,Saudi Arabia
5.Department of Chemistry,SBA School of Science & Engineering,Lahore University of Management Sciences,Lahore Cantt.,54792,Pakistan
6.Department of Chemistry,College of Science,Southern University of Science and Technology,Shenzhen,518055,China

Irfan，Jaffar,Ali，Arshad,Hussain，Muhammad Ajaz,et al. A superabsorbent and pH-responsive copolymer-hydrogel based on acemannan from Aloe vera (Aloe barbadensis M.): A smart material for drug delivery[J]. International Journal of Biological Macromolecules,2024,270.

Irfan，Jaffar.,Ali，Arshad.,Hussain，Muhammad Ajaz.,Haseeb，Muhammad Tahir.,Alsahli，Tariq G..,...&Azhar，Irfan.(2024).A superabsorbent and pH-responsive copolymer-hydrogel based on acemannan from Aloe vera (Aloe barbadensis M.): A smart material for drug delivery.International Journal of Biological Macromolecules,270.

Irfan，Jaffar,et al."A superabsorbent and pH-responsive copolymer-hydrogel based on acemannan from Aloe vera (Aloe barbadensis M.): A smart material for drug delivery".International Journal of Biological Macromolecules 270(2024).