Displacement-pressure biparametrically regulated softness sensory system for intraocular pressure monitoring

Cheng，Yu1; Zhan，Yifei1; Guan，Fangyi1; Shi，Junli1; Wang，Jingxiao1; Sun，Yi1; Zubair，Muhammad2; Yu，Cunjiang2,3,4; Guo，Chuan Fei1

2024-06-01

10.1093/nsr/nwae050

National Science Review   影响因子和分区

2095-5138

2053-714X

High intraocular pressure (IOP) is one of the high-risk pathogenic factors of glaucoma. Existing methods of IOP measurement are based on the direct interaction with the cornea. Commercial ophthalmic tonometers based on snapshot measurements are expensive, bulky, and their operation requires trained personnel. Theranostic contact lenses are easy to use, but they may block vision and cause infection. Here, we report a sensory system for IOP assessment that uses a soft indentor with two asymmetrically deployed iontronic flexible pressure sensors to interact with the eyelid-eyeball in an eye-closed situation. Inspired by human fingertip assessment of softness, the sensory system extracts displacement-pressure information for soft evaluation, achieving high accuracy IOP monitoring (>96%). We further design and custom-make a portable and wearable ophthalmic tonometer based on the sensory system and demonstrate its high efficacy in IOP screening. This sensory system paves a way towards cost-effective, robust, and reliable IOP monitoring.

deep learning intraocular pressure iontronic sensor softness tonometer

SCI ; EI

英语

第一

2-s2.0-85192672037

Scopus

1.Department of Materials Science and Engineering,Southern University of Science and Technology,Shenzhen,518055,China
2.Department of Engineering Science and Mechanics,Pennsylvania State University,State College,16802,United States
3.Department of Biomedical Engineering,Pennsylvania State University,State College,16802,United States
4.Department of Materials Science and Engineering,Materials Research Institute,Pennsylvania State University,State College,16802,United States

Cheng，Yu,Zhan，Yifei,Guan，Fangyi,et al. Displacement-pressure biparametrically regulated softness sensory system for intraocular pressure monitoring[J]. National Science Review,2024,11(6).

Cheng，Yu.,Zhan，Yifei.,Guan，Fangyi.,Shi，Junli.,Wang，Jingxiao.,...&Guo，Chuan Fei.(2024).Displacement-pressure biparametrically regulated softness sensory system for intraocular pressure monitoring.National Science Review,11(6).

Cheng，Yu,et al."Displacement-pressure biparametrically regulated softness sensory system for intraocular pressure monitoring".National Science Review 11.6(2024).