Association between per- and poly-fluoroalkyl substances and nonalcoholic fatty liver disease: A nested case-control study in northwest China

Wu，Yuanqin1; Cheng，Zhiyuan2; Zhang，Wei3; Yin，Chun4; Sun，Jianyun5; Hua，Honghao1; Long，Xianzhen1; Wu，Xijiang4; Wang，Yufeng4; Ren，Xiaoyu3; Zhang，Desheng4; Bai，Yana1; Li，Yongjun5; Cheng，Ning3

2024-06-01

10.1016/j.envpol.2024.123937

Environmental Pollution   影响因子和分区

0269-7491

1873-6424

Per- and poly-fluoroalkyl substances (PFAS) have been reported to have hepatotoxic effects. However, it is unclear whether they are linked to non-alcoholic fatty liver disease (NAFLD). This nested case-control study focused on the epidemiological links between PFAS and the prevalence of NAFLD. We selected 476 new cases of NAFLD and 952 age- and sex-matched controls from the Jinchang cohort population between 2014 and 2019. Serum concentrations of PFAS were measured using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Only PFAS with a detection rate of ≥90 % were included for analysis, which included PFPeA, PFOA, PFNA, PFHxS, PFOS, and 9Cl-PF3ONS. The relationship between single and co-exposure to PFAS and the occurrence of NAFLD was evaluated using conditional logistic regression, Quantile g-computation (QgC), and Bayesian kernel machine regression (BKMR) model. Logistic regression indicated that PFPeA, PFOA, and 9Cl-PF3ONS were positive correlation with the incidence of NAFLD after adjusting for confounders, with odds ratios (OR) and 95 % confidence interval (CI) of 3.13 (95 % CI: 2.53, 3.86), 1.39 (95 % CI: 1.12, 1.73), and 1.41 (95 % CI: 1.20, 1.66), respectively. PFNA, PFHxS, and PFOS were nonlinearly and negatively associated with the incidence of NAFLD, with OR (95 % CI) of 0.53 (0.46, 0.62), 0.83 (0.73, 0.95), and 0.52 (0.44, 0.61), respectively. QgC showed a significant joint effect of PFAS mixture on NAFLD onset (OR: 1.52, 95 % CI: 1.24, 1.88). BKMR showed a weak positive trend between PFAS mixtures and NAFLD incidence. Positive correlations were primarily driven by PFPeA and 9Cl-PF3ONS, while negative correlations were mainly influenced by PFNA and PFOS. The BKMR model also suggested that there was an interaction between PFOS and PFNA and other four PFAS compounds. In conclusion, our findings suggest that individual and co-exposure to PFAS is associated with a risk of NAFLD onset.

BKMR Incidence Nonalcoholic fatty liver disease per- and poly-fluoroalkyl substances QgC

SCI ; EI

英语

其他

ENVIRONMENT/ECOLOGY

2-s2.0-85192101320

Scopus

1.Institute of Epidemiology and Statistics,School of Public Health,Lanzhou University,Lanzhou,Gansu,China
2.School of Public Health and Emergency Management,Southern University of Science and Technology,Shenzhen,China
3.Basic Medical College,Lanzhou University,Lanzhou,Gansu,China
4.Workers' Hospital of Jinchuan Group Co.,Ltd.,Jinchang,Gansu,China
5.Physical and Chemical Laboratory,Center for Disease Control and Prevention of Gansu,China

Wu，Yuanqin,Cheng，Zhiyuan,Zhang，Wei,et al. Association between per- and poly-fluoroalkyl substances and nonalcoholic fatty liver disease: A nested case-control study in northwest China[J]. Environmental Pollution,2024,350.

Wu，Yuanqin.,Cheng，Zhiyuan.,Zhang，Wei.,Yin，Chun.,Sun，Jianyun.,...&Cheng，Ning.(2024).Association between per- and poly-fluoroalkyl substances and nonalcoholic fatty liver disease: A nested case-control study in northwest China.Environmental Pollution,350.

Wu，Yuanqin,et al."Association between per- and poly-fluoroalkyl substances and nonalcoholic fatty liver disease: A nested case-control study in northwest China".Environmental Pollution 350(2024).