Injectable hydrogel harnessing foreskin mesenchymal stem cell-derived extracellular vesicles for treatment of chronic diabetic skin wounds

Xu，Chang1; Cao，Jin Feng2,3; Pei，Yue1; Kim，Yujin9; Moon，Huiyeon9; Fan，Chui Qin1; Liao，Mao Chuan1; Wang，Xing Yu8; Yao，Fei4; Zhang，Yu Jun1; Zhang，Shao Hui5; Zhang，Jian5; Li，Jian Zhang2,3; Kim，Jong Seung9; Ma，Lian1,6,7; Xie，Zhong Jian1,10

2024-06-01

10.1016/j.jconrel.2024.04.049

Journal of Controlled Release   影响因子和分区

0168-3659

1873-4995

Chronic skin wounds are a serious complication of diabetes with a high incidence rate, which can lead to disability or even death. Previous studies have shown that mesenchymal stem cells derived extracellular vesicles (EVs) have beneficial effects on wound healing. However, the human foreskin mesenchymal stem cell (FSMSCs)-derived extracellular vesicle (FM-EV) has not yet been isolated and characterized. Furthermore, the limited supply and short lifespan of EVs also hinder their practical use. In this study, we developed an injectable dual-physical cross-linking hydrogel (PSiW) with self-healing, adhesive, and antibacterial properties, using polyvinylpyrrolidone and silicotungstic acid to load FM-EV. The EVs were evenly distributed in the hydrogel and continuously released. In vivo and vitro tests demonstrated that the synergistic effect of EVs and hydrogel could significantly promote the repair of diabetic wounds by regulating macrophage polarization, promoting angiogenesis, and improving the microenvironment. Overall, the obtained EVs-loaded hydrogels developed in this work exhibited promising applicability for the repair of chronic skin wounds in diabetes patients.

Diabetic wound healing Extracellular vesicles Foreskin-derived mesenchymal stem cells Hydrogel Multifunctional wound dressing

SCI ; EI

英语

第一

PHARMACOLOGY & TOXICOLOGY

2-s2.0-85191949796

Scopus

1.Institute of Pediatrics,Shenzhen Children's Hospital,Clinical Medical College of Southern University of Science and Technology,Shenzhen,518038,China
2.Beijing Key Laboratory of Wood Science and Engineering,Beijing Forestry University,Beijing,100083,China
3.Key Laboratory of Wood Material Science and Application (Beijing Forestry University),Ministry of Education,Beijing,100083,China
4.Eye Center of Xiangya Hospital,Central South University,Changsha,410000,China
5.Institute of Materials Science and Devices,School of Materials Science and Engineering,Suzhou University of Science and Technology,Suzhou,215009,China
6.Department of Hematology and Oncology,Shenzhen Children's Hospital,Shenzhen,518038,China
7.Department of Pediatrics,The Third Affifiliated Hospital of Guangzhou Medical University,Guangzhou,510150,China
8.Department of Emergency,ChangYang Tujia Autonomous County People's Hospital,Yichang,443000,China
9.Department of Chemistry,Korea University,Seoul,02841,South Korea
10.Shenzhen International Institute for Biomedical Research,Shenzhen,Guangdong,518116,China

Xu，Chang,Cao，Jin Feng,Pei，Yue,et al. Injectable hydrogel harnessing foreskin mesenchymal stem cell-derived extracellular vesicles for treatment of chronic diabetic skin wounds[J]. Journal of Controlled Release,2024,370:339-353.

Xu，Chang.,Cao，Jin Feng.,Pei，Yue.,Kim，Yujin.,Moon，Huiyeon.,...&Xie，Zhong Jian.(2024).Injectable hydrogel harnessing foreskin mesenchymal stem cell-derived extracellular vesicles for treatment of chronic diabetic skin wounds.Journal of Controlled Release,370,339-353.

Xu，Chang,et al."Injectable hydrogel harnessing foreskin mesenchymal stem cell-derived extracellular vesicles for treatment of chronic diabetic skin wounds".Journal of Controlled Release 370(2024):339-353.