Survival nomograms for vulvar squamous cell carcinoma based on the SEER database and a Chinese external validation cohort

Zhao，Zhongyi1,2; Zhen，Shihan3; Liu，Ning2; Ding，Ding2; Zhang，Dandan4; Kong，Juan2

2024-06-01

10.1002/ijgo.15313

International Journal of Gynecology and Obstetrics   影响因子和分区

0020-7292

1879-3479

Objective: The aim of study was to construct a nomogram to effectively predict the overall survival (OS) and cancer-specific survival (CSS) for patients with vulvar squamous cell carcinoma (VSCC). Methods: The training cohort consisted of 5405 patients with VSCC, extracted from the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2015. Eighty-four patients with VSCC were selected from the disease database of the Shengjing Hospital of China Medical University from 2014 to 2020, and enrolled as the external validation cohort. Significant independent prognostic factors were identified using Cox regression analysis and used to develop nomograms to predict 1-, 3-, and 5-year OS and CSS in patients with VSCC. Results: The nomogram predicting OS was developed based on tumor size, histological grade, International Federation of Gynecology and Obstetrics (FIGO) stage, regional lymph node involvement, distant metastases, surgery, chemotherapy, age, and race. The nomogram for CSS was constructed using the similar factors, excluding race but including marital status. The nomogram for 1-, 3-, and 5-year OS demonstrated robust performance with receiver operating characteristic curves (AUCs) exceeding 80% (0.86, 0.84, and 0.82), outperforming the FIGO staging alone (0.77, 0.75, and 0.72). Similarly, for CSS, our nomograms achieved larger AUCs of 0.89, 0.88, and 0.86 compared with FIGO staging alone (0.81, 0.79, and 0.78). Conclusion: The nomograms more accurately predict prognosis than simple FIGO staging. Moreover, the nomograms developed in this study provide a convenient, operable, and reliable tool for individual assessment and clinical decision-making for patients with VSCC.

cancer-specific survival nomogram overall survival SEER database vulvar squamous cell carcinoma

SCI

英语

其他

2-s2.0-85190896929

Scopus

1.Department of Health Management,Shengjing Hospital of China Medical University,Shenyang,China
2.Department of Clinical Nutrition,Shengjing Hospital of China Medical University,Shenyang,China
3.School of Public Health and Emergency Management,Southern University of Science and Technology,Shenzhen,China
4.Department of Obstetrics and Gynecology,Shengjing Hospital of China Medical University,Shenyang,China

Zhao，Zhongyi,Zhen，Shihan,Liu，Ning,et al. Survival nomograms for vulvar squamous cell carcinoma based on the SEER database and a Chinese external validation cohort[J]. International Journal of Gynecology and Obstetrics,2024,165(3):1130-1143.

Zhao，Zhongyi,Zhen，Shihan,Liu，Ning,Ding，Ding,Zhang，Dandan,&Kong，Juan.(2024).Survival nomograms for vulvar squamous cell carcinoma based on the SEER database and a Chinese external validation cohort.International Journal of Gynecology and Obstetrics,165(3),1130-1143.

Zhao，Zhongyi,et al."Survival nomograms for vulvar squamous cell carcinoma based on the SEER database and a Chinese external validation cohort".International Journal of Gynecology and Obstetrics 165.3(2024):1130-1143.