Fast and Stable Antibacterial Coating of Photosensitive Aggregation-Induced Emission Luminogens for Disinfection on Medical Devices

Chen，Mian1; Dong，Ruihua2; Song，Jiayi1; Qi，Jie3; Zhang，Jiangjiang3; Zhao，Zheng1,2; Zhang，Wentian1; Li，Ying1; Tang，Ben Zhong2

2024-05-17

10.1002/adhm.202303967

Advanced Healthcare Materials   影响因子和分区

2192-2640

2192-2659

Aggregation-induced emission luminogens (AIEgens) are promising photosensitizers that have exhibited excellent antibacterial ability with abundant reactive oxygen species (ROS) generation. TTCPy-PF6 and TTCPy-Br are deposited on the surface of diverse solid substrates through plasma-assistant electrostatic self-assembly. The AIEgens-covered coating can effectively eliminate different pathogenic Gram-positive (G+) bacteria and even their multidrug-resistant (MDR) mutants with negligible side effects such as cytotoxicity, hemolysis, and inflammation. Moreover, the AIEgen-coated surface can maintain high stability for long-time antibacterial usage, which is dependent on the ROS-mediated disruption of the attached bacteria. The AIEgen-based coatings with broad surface applicability have many advantages in high antibacterial ability, great biocompatibility, and low possibility of antibiotic pollution. The robust antibacterial ability and excellent biological safety of the AIEgen-based coatings would be helpful for the disinfection of medical devices.

aggregation-induced emission AIEgen-covered coating antibacterial ability multidrug-resistant (MDR) mutants

SCI ; EI

英语

其他

2-s2.0-85185120928

Scopus

1.Innovation Research Center for AIE Pharmaceutical Biology,Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology,the NMPA and State Key Laboratory of Respiratory Disease,School of Pharmaceutical Sciences and the Fifth Affiliated Hospital,Guangzhou Medical University,Guangzhou,511436,China
2.Clinical Translational Research Center of Aggregation-Induced Emission,The Second Affiliated Hospital,School of Medicine,School of Science and Engineering,Shenzhen Institute of Aggregate Science and Technology,The Chinese University of Hong Kong,Shenzhen,518172,China
3.Shenzhen Key Laboratory of Smart Healthcare Engineering and Guangdong Provincial Key Laboratory of Advanced Biomaterials,Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,No 1088, Xueyuan Rd., Nanshan District,518055,China

Chen，Mian,Dong，Ruihua,Song，Jiayi,et al. Fast and Stable Antibacterial Coating of Photosensitive Aggregation-Induced Emission Luminogens for Disinfection on Medical Devices[J]. Advanced Healthcare Materials,2024,13(13).

Chen，Mian.,Dong，Ruihua.,Song，Jiayi.,Qi，Jie.,Zhang，Jiangjiang.,...&Tang，Ben Zhong.(2024).Fast and Stable Antibacterial Coating of Photosensitive Aggregation-Induced Emission Luminogens for Disinfection on Medical Devices.Advanced Healthcare Materials,13(13).

Chen，Mian,et al."Fast and Stable Antibacterial Coating of Photosensitive Aggregation-Induced Emission Luminogens for Disinfection on Medical Devices".Advanced Healthcare Materials 13.13(2024).