A Bioinspired and Cost-Effective Device for Minimally Invasive Blood Sampling

Zoratto，Nicole1; Klein-Cerrejon，David1; Gao，Daniel1; Inchiparambil，Tino1; Sachs，David2; Luo，Zhi3; Leroux，Jean Christophe1

2024-05-15

10.1002/advs.202308809

Advanced Science   影响因子和分区

2198-3844

Conventional venipuncture is invasive and challenging in low and middle-income countries. Conversely, point-of-care devices paired with fingersticks, although less invasive, suffer from high variability and low blood volume collection. Recently approved microsampling devices address some of these issues but remain cost-prohibitive for resource-limited settings. In this work, a cost-effective microsampling device is described for the collection of liquid blood with minimal invasiveness and sufficient volume retrieval for laboratory analyses or immediate point-of-care testing. Inspired by the anatomy of sanguivorous leeches, the single-use device features a storage compartment for blood collection and a microneedle patch hidden within a suction cup. Finite Element Method simulations, corroborated by mechanical analyses, guide the material selection for device fabrication and design optimization. In piglets, the device successfully collects ≈195 µL of blood with minimal invasiveness. Additionally, a tailor-made lid and adapter enable safe fluid transportation and integration with commercially available point-of-care systems for on-site analyses, respectively. Taken together, the proposed platform holds significant promise for enhancing healthcare in the pediatric population by improving patient compliance and reducing the risk of needlestick injuries through concealed microneedles. Most importantly, given its cost-effective fabrication, the open-source microsampling device may have a meaningful impact in resource-limited healthcare settings.

bioinspired and cost-effective device blood microsampling concealed microneedles minimal-invasiveness point-of-care combination

SCI ; EI

英语

其他

2-s2.0-85186879984

Scopus

1.Institute of Pharmaceutical Sciences,Department of Chemistry and Applied Biosciences,ETH,Zurich,8093,Switzerland
2.Institute for Mechanical Systems,Department of Mechanical and Process Engineering,ETH,Zurich,8093,Switzerland
3.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China

Zoratto，Nicole,Klein-Cerrejon，David,Gao，Daniel,et al. A Bioinspired and Cost-Effective Device for Minimally Invasive Blood Sampling[J]. Advanced Science,2024,11(18).

Zoratto，Nicole.,Klein-Cerrejon，David.,Gao，Daniel.,Inchiparambil，Tino.,Sachs，David.,...&Leroux，Jean Christophe.(2024).A Bioinspired and Cost-Effective Device for Minimally Invasive Blood Sampling.Advanced Science,11(18).

Zoratto，Nicole,et al."A Bioinspired and Cost-Effective Device for Minimally Invasive Blood Sampling".Advanced Science 11.18(2024).