MXBOTs: Biodegradable Ti3C2 MXene-Based Microrobots for Targeted Delivery and Synergistic Chemo-Photothermal Therapy

Yang，Ming1,2; Xie，Hanhan2; Jiang，Tiancheng3; Zhan，Zhen2; Ye，Min4; Yue，Tao5; Yan，Xiaohui3; Wang，Xiaopu4; Hu，Chengzhi2,6

2024-05-06

10.1021/acsmaterialslett.4c00472

ACS Materials Letters   影响因子和分区

2639-4979

Functions such as biocompatibility, degradability, therapeutics, and imaging are critical for use of microrobots in clinical scenarios; however, incorporation of these functions into a single microrobotic entity is still challenging. Herein, we report multifunctional TiC MXene-based magnetically actuated microrobots (MXBOTs), which are prepared by sequentially electrostatic coating of TiC nanosheets and FeO nanoparticles on the surface of biodegradable gelatin methacryloyl (GelMA)-based helical microstructures. These MXBOTs can move along predefined paths under a rotating magnetic field. The incorporation of TiC nanosheets provides MXBOTs with an advantageous photothermal effect and photoacoustic (PA) imaging capability. Additionally, MXBOTs can be loaded with fluorescent molecules, enabling fluorescence imaging. After loading the chemotherapeutic drug DOX, the MXBOTs@DOX were able to accelerate the release of DOX under the stimulation of temperature and acidic pH. This work presents a viable approach for developing biodegradable and functional microrobots for targeted delivery and synergistic chemo-photothermal therapy.

SCI ; EI

英语

其他

2-s2.0-85189531950

Scopus

1.School of Mechatronics Engineering,Harbin Institute of Technology,Harbin,150001,China
2.Shenzhen Key Laboratory of Biomimetic Robotics and Intelligent Systems,Department of Mechanical and Energy Engineering,Southern University of Science and Technology,Shenzhen,518055,China
3.State Key Laboratory of Vaccines for Infectious Diseases,School of Public Health,Xiamen University,Xiamen,361005,China
4.Shenzhen Institute of Artificial Intelligence and Robotics for Society,Shenzhen,Guangdong,518129,China
5.School of Mechatronics Engineering and Automation,Shanghai University,Shanghai,200444,China
6.Guangdong Provincial Key Laboratory of Human-Augmentation and Rehabilitation Robotics in Universities,Southern University of Science and Technology,Shenzhen,518055,China

Yang，Ming,Xie，Hanhan,Jiang，Tiancheng,et al. MXBOTs: Biodegradable Ti3C2 MXene-Based Microrobots for Targeted Delivery and Synergistic Chemo-Photothermal Therapy[J]. ACS Materials Letters,2024,6(5):1801-1810.

Yang，Ming.,Xie，Hanhan.,Jiang，Tiancheng.,Zhan，Zhen.,Ye，Min.,...&Hu，Chengzhi.(2024).MXBOTs: Biodegradable Ti3C2 MXene-Based Microrobots for Targeted Delivery and Synergistic Chemo-Photothermal Therapy.ACS Materials Letters,6(5),1801-1810.

Yang，Ming,et al."MXBOTs: Biodegradable Ti3C2 MXene-Based Microrobots for Targeted Delivery and Synergistic Chemo-Photothermal Therapy".ACS Materials Letters 6.5(2024):1801-1810.