南方科技大学知识苑(SUSTech KC): A spatiotemporal atlas of mouse liver homeostasis and regeneration

题名	A spatiotemporal atlas of mouse liver homeostasis and regeneration
作者	Xu，Jiangshan 1,2; Guo，Pengcheng 3,4; Hao，Shijie 1,2,5; Shangguan，Shuncheng 2,6; Shi，Quan 7; Volpe，Giacomo 8; Huang，Keke 9; Zuo，Jing 1,2; An，Juan 10,11; Yuan，Yue 1,2; Cheng，Mengnan 1,2; Deng，Qiuting 1,2,5; Zhang，Xiao 3; Lai，Guangyao 6,11; Nan，Haitao 12; Wu，Baihua 12; Shentu，Xinyi 12; Wu，Liang 11; Wei，Xiaoyu 1,2; Jiang，Yujia 1,2; Huang，Xin 2,5; Pan，Fengyu 1,2; Song，Yumo 1,2; Li，Ronghai 1,2; Wang，Zhifeng 1,2; Liu，Chuanyu 1,2,13; Liu，Shiping 1,2; Li，Yuxiang 2; Yang，Tao 14,15; Xu，Zhicheng 14,15; Du，Wensi 14,15; Li，Ling 14,15; Ahmed，Tanveer 16; You，Kai 16; Dai，Zhen 16; Li，Li 11,16; Qin，Baoming 16; Li，Yinxiong 16; Lai，Liangxue 16; Qin，Dajiang 17; Chen，Junling 18; Fan，Rong 18; Li，Yongyin 18; Hou，Jinlin 18; Ott，Michael 19; Sharma，Amar Deep 19; Cantz，Tobias 19; Schambach，Axel 20,21; Kristiansen，Karsten 7; Hutchins，Andrew P.22 ; Göttgens，Berthold 23; Maxwell，Patrick H.24; Hui，Lijian 12; Xu，Xun 1,2,13,25; Liu，Longqi 1,5,13; Chen，Ao 2,7,26,27; Lai，Yiwei 1,2,4,13; Esteban，Miguel A.3,4,9,11,17,21
通讯作者	Xu，Xun; Liu，Longqi; Chen，Ao; Lai，Yiwei; Esteban，Miguel A.
发表日期	2024-05-01
DOI	10.1038/s41588-024-01709-7
发表期刊	Nature Genetics 影响因子和分区
ISSN	1061-4036
EISSN	1546-1718
卷号	56 期号:5页码:953-969
摘要	The mechanism by which mammalian liver cell responses are coordinated during tissue homeostasis and perturbation is poorly understood, representing a major obstacle in our understanding of many diseases. This knowledge gap is caused by the difficulty involved with studying multiple cell types in different states and locations, particularly when these are transient. We have combined Stereo-seq (spatiotemporal enhanced resolution omics-sequencing) with single-cell transcriptomic profiling of 473,290 cells to generate a high-definition spatiotemporal atlas of mouse liver homeostasis and regeneration at the whole-lobe scale. Our integrative study dissects in detail the molecular gradients controlling liver cell function, systematically defining how gene networks are dynamically modulated through intercellular communication to promote regeneration. Among other important regulators, we identified the transcriptional cofactor TBL1XR1 as a rheostat linking inflammation to Wnt/β-catenin signaling for facilitating hepatocyte proliferation. Our data and analytical pipelines lay the foundation for future high-definition tissue-scale atlases of organ physiology and malfunction.
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
学校署名	其他
ESI学科分类	MOLECULAR BIOLOGY & GENETICS
Scopus记录号	2-s2.0-85190697199
来源库	Scopus
引用统计	被引频次[WOS]：7
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/761185
专题	生命科学学院_生物系生命科学学院
作者单位	1.BGI Research,Hangzhou,China 2.BGI Research,Shenzhen,China 3.State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases,Key Laboratory for Zoonosis Research of the Ministry of Education,Institute of Zoonosis,and College of Veterinary Medicine,Jilin University,Changchun,China 4.3DC STAR,Shenzhen,Spatiotemporal Campus at BGI Shenzhen,China 5.College of Life Sciences,University of Chinese Academy of Sciences,Beijing,China 6.Joint School of Life Sciences,Guangzhou Institutes of Biomedicine and Health and Guangzhou Medical University,Guangzhou,China 7.Department of Biology,University of Copenhagen,Copenhagen,Denmark 8.Hematology and Cell Therapy Unit,IRCCS-Istituto Tumori ‘Giovanni Paolo II’,Bari,Italy 9.Faculty of Medicine,Chulalongkorn University,Bangkok,Thailand 10.School of Life Sciences,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei,China 11.Laboratory of Integrative Biology,Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,Guangzhou,China 12.State Key Laboratory of Cell Biology,CAS Center for Excellence in Molecular Cell Science,Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,Shanghai,China 13.BGI Collaborative Center for Future Medicine,Shanxi Medical University,Taiyuan,China 14.China National GeneBank,BGI Research,Shenzhen,China 15.Guangdong Provincial Genomics Data Center,BGI Research,Shenzhen,China 16.Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine,CAS Key Laboratory of Regenerative Biology,Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,Guangzhou,China 17.The Fifth Affiliated Hospital of Guangzhou Medical University–BGI Research Center for Integrative Biology,The Fifth Affiliated Hospital of Guangzhou Medical University,Guangzhou,China 18.Department of Infectious Diseases,Nanfang Hospital,Southern Medical University,Guangdong Provincial Key Laboratory of Viral Hepatitis Research,Guangzhou,China 19.Department of Gastroenterology,Hepatology and Endocrinology,Hannover Medical School,Hannover,Germany 20.Division of Hematology/Oncology,Boston Children’s Hospital,Harvard Medical School,Boston,United States 21.Institute of Experimental Hematology,Hannover Medical School,Hannover,Germany 22.Shenzhen Key Laboratory of Gene Regulation and Systems Biology,Department of Biology,School of Life Sciences,Southern University of Science and Technology,Shenzhen,China 23.Department of Haematology and Wellcome MRC Cambridge Stem Cell Institute,University of Cambridge,Cambridge,United Kingdom 24.Cambridge Institute for Medical Research,Department of Medicine,University of Cambridge,Cambridge,United Kingdom 25.Guangdong Provincial Key Laboratory of Genome Read and Write,Shenzhen,China 26.BGI Research,Chongqing,China 27.JFL-BGI STOmics Center,BGI-Shenzhen,Chongqing,China
推荐引用方式 GB/T 7714	Xu，Jiangshan,Guo，Pengcheng,Hao，Shijie,et al. A spatiotemporal atlas of mouse liver homeostasis and regeneration[J]. Nature Genetics,2024,56(5):953-969.
APA	Xu，Jiangshan.,Guo，Pengcheng.,Hao，Shijie.,Shangguan，Shuncheng.,Shi，Quan.,...&Esteban，Miguel A..(2024).A spatiotemporal atlas of mouse liver homeostasis and regeneration.Nature Genetics,56(5),953-969.
MLA	Xu，Jiangshan,et al."A spatiotemporal atlas of mouse liver homeostasis and regeneration".Nature Genetics 56.5(2024):953-969.