Epigenetic regulations of cellular senescence in osteoporosis

Shaochuan Huo1,2; Xinzheng Tang1,2; Weijian Chen3; Donghao Gan4; Hai Guo5; Qing Yao4; Rongdong Liao6; Tingting Huang3; Junxian Wu1; Junxing Yang1,2; Guozhi Xiao4; Xia Han1,2

2024-02

10.1016/j.arr.2024.102235

Ageing Research Reviews   影响因子和分区

1568-1637

1872-9649

Osteoporosis (OP) is a prevalent age-related disease that is characterized by a decrease in bone mineral density (BMD) and systemic bone microarchitectural disorders. With age, senescent cells accumulate and exhibit the senescence-associated secretory phenotype (SASP) in bone tissue, leading to the imbalance of bone homeostasis, osteopenia, changes in trabecular bone structure, and increased bone fragility. Cellular senescence in the bone microenvironment involves osteoblasts, osteoclasts, and bone marrow mesenchymal stem cells (BMSCs), whose effects on bone homeostasis are regulated by epigenetics. Therefore, the epigenetic regulatory mechanisms of cellular senescence have received considerable attention as potential targets for preventing and treating osteoporosis. In this paper, we systematically review the mechanisms of aging-associated epigenetic regulation in osteoporosis, emphasizing the impact of epigenetics on cellular senescence, and summarize three current methods of targeting cellular senescence, which is helpful better to understand the pathogenic mechanisms of cellular senescence in osteoporosis and provides strategies for the development of epigenetic drugs for the treatment of osteoporosis.

Cellular senescence Epigenetic regulations Osteoporosis Pathogenic mechanism

SCI

英语

共同第一 ; 通讯

CLINICAL MEDICINE

2-s2.0-85195536466

人工提交

1.Shenzhen Hospital of Guangzhou University of Chinese Medicine (Futian), Shenzhen 518000, China
2.Shenzhen Research Institute of Guangzhou University of Traditional Medicine (Futian), Shenzhen 518000, China
3.Guangzhou University of Chinese Medicine, Guangzhou 510405, China
4.Department of Biochemistry, School of Medicine, Shenzhen Key Laboratory of Cell Microenvironment, Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Southern University of Science and Technology, Shenzhen 518055, China
5.Liuzhou Traditional Chinese Medicine Hospital (Liuzhou Zhuang Medical Hospital), Liuzhou 545001, China
6.Department of Orthopaedics, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China
7.Shenzhen Hospital of Guangzhou University of Chinese Medicine (Futian), Shenzhen 518000, China
8.Shenzhen Research Institute of Guangzhou University of Traditional Medicine (Futian), Shenzhen 518000, China
9.Guangzhou University of Chinese Medicine, Guangzhou 510405, China
10.Department of Biochemistry, School of Medicine, Shenzhen Key Laboratory of Cell Microenvironment, Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Southern University of Science and Technology, Shenzhen 518055, China
11.Liuzhou Traditional Chinese Medicine Hospital (Liuzhou Zhuang Medical Hospital), Liuzhou 545001, China
12.Department of Orthopaedics, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China

Shaochuan Huo,Xinzheng Tang,Weijian Chen,et al. Epigenetic regulations of cellular senescence in osteoporosis[J]. Ageing Research Reviews,2024,99:102235.

Shaochuan Huo.,Xinzheng Tang.,Weijian Chen.,Donghao Gan.,Hai Guo.,...&Xia Han.(2024).Epigenetic regulations of cellular senescence in osteoporosis.Ageing Research Reviews,99,102235.

Shaochuan Huo,et al."Epigenetic regulations of cellular senescence in osteoporosis".Ageing Research Reviews 99(2024):102235.