Neurobiological basis of emergence from anesthesia

Song, Xue-Jun1,2; Hu, Jiang-Jian1,2

2024-05-01

10.1016/j.tins.2024.02.006

TRENDS IN NEUROSCIENCES   影响因子和分区

0166-2236

1878-108X

The suppression of consciousness by anesthetics and the emergence of the brain from anesthesia are complex and elusive processes. Anesthetics may exert their inhibitory effects by binding to specific protein targets or through membrane-mediated targets, disrupting neural activity and the integrity and function of neural circuits responsible for signal transmission and conscious perception/subjective experience. Emergence from anesthesia was generally thought to depend on the elimination of the anesthetic from the body. Recently, studies have suggested that emergence from anesthesia is a dynamic and active process that can be partially controlled and is independent of the specific molecular targets of anesthetics. This article summarizes the fundamentals of anesthetics' actions in the brain and the mechanisms of emergence from anesthesia that have been recently revealed in animal studies.

SCI

英语

第一 ; 通讯

National Natural Science Foundation of China[NSFC82350710225]

Neurosciences & Neurology

Neurosciences

WOS:001241316700001

CELL PRESS

NEUROSCIENCE & BEHAVIOR

Web of Science

1.Southern Univ Sci & Technol, Sch Med, Dept Med Neurosci, Shenzhen, Peoples R China
2.Southern Univ Sci & Technol, SUSTech Ctr Pain Med, Sch Med, Shenzhen, Peoples R China

Song, Xue-Jun,Hu, Jiang-Jian. Neurobiological basis of emergence from anesthesia[J]. TRENDS IN NEUROSCIENCES,2024,47(5).

Song, Xue-Jun,&Hu, Jiang-Jian.(2024).Neurobiological basis of emergence from anesthesia.TRENDS IN NEUROSCIENCES,47(5).

Song, Xue-Jun,et al."Neurobiological basis of emergence from anesthesia".TRENDS IN NEUROSCIENCES 47.5(2024).