近红外二区稠环受体分子开发及荧光成像 和光热治疗应用

近红外二区窗口（NIR-II，1000-3000 nm）具有更好的生物组织穿透性，因而成为光学诊疗的热点平台。然而，开发在长波长区域响应的高效光学诊疗剂是一个重大挑战。本文基于A-D-A型稠环受体结构，通过引入醌式结构的桥单元，开发了两种新型的NIR-II光学诊疗剂。通过引入噻吩并[3,4-b]吡嗪作为桥单元，合成了CNTIC-4F分子。它的水溶性纳米粒子在水中吸收超过1200 nm，荧光发射可以达到1800 nm。在1064 nm激光照射下，CNTIC-4F纳米粒子表现出82%的高光热转换效率，表现出高效的肿瘤热消融效果。以噻吩并[3,2-b]噻吩结构作为桥单元合成了CTTIC-4F分子。经过包裹处理后的CTTIC-4F纳米粒子在水中的吸收波长超过1000 nm，荧光量子产率高达0.46%。在1064 nm激光激发下，小鼠腿部、脑部血管成像信噪比高达6.77。研究结果为设计长波长吸收/发射的NIR-II光学诊疗剂提供了一种有效策略。

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