| 题名 | Accelerating 3D genomics data analysis with Microcket |
| 作者 | |
| 通讯作者 | Sun，Kun |
| 发表日期 | 2024-12-01
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| DOI | |
| 发表期刊 | |
| EISSN | 2399-3642
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| 卷号 | 7期号:1 |
| 摘要 | The three-dimensional (3D) organization of genome is fundamental to cell biology. To explore 3D genome, emerging high-throughput approaches have produced billions of sequencing reads, which is challenging and time-consuming to analyze. Here we present Microcket, a package for mapping and extracting interacting pairs from 3D genomics data, including Hi-C, Micro-C, and derivant protocols. Microcket utilizes a unique read-stitch strategy that takes advantage of the long read cycles in modern DNA sequencers; benchmark evaluations reveal that Microcket runs much faster than the current tools along with improved mapping efficiency, and thus shows high potential in accelerating and enhancing the biological investigations into 3D genome. Microcket is freely available at https://github.com/hellosunking/Microcket. |
| 相关链接 | [Scopus记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 其他
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| Scopus记录号 | 2-s2.0-85194997608
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| 来源库 | Scopus
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| 引用统计 | |
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/778535 |
| 专题 | 生命科学学院_生物系 生命科学学院 |
| 作者单位 | 1.Molecular Cancer Research Center,School of Medicine,Sun Yat-sen University,Shenzhen,Shenzhen Campus of Sun Yat-sen University,518107,China 2.Institute of Cancer Research,Shenzhen Bay Laboratory,Shenzhen,518132,China 3.Department of Chemical and Biological Engineering,Division of Life Science,Hong Kong University of Science and Technology,999077,Hong Kong 4.Department of Biology,School of Life Sciences,Southern University of Science and Technology,Shenzhen,518055,China 5.Institute of Systems and Physical Biology,Shenzhen Bay Laboratory,Shenzhen,518132,China 6.Department of Genetics and Genome Sciences,School of Medicine,Case Western Reserve University,Cleveland,44106,United States 7.State Key Laboratory of Cellular Stress Biology,Fujian Provincial Key Laboratory of Reproductive Health Research,Fujian Provincial Key Laboratory of Organ and Tissue Regeneration,School of Medicine,Faculty of Medicine and Life Sciences,Xiamen University,Xiamen,361102,China |
| 推荐引用方式 GB/T 7714 |
Zhao，Yu,Yang，Mengqi,Gong，Fanglei,et al. Accelerating 3D genomics data analysis with Microcket[J]. Communications Biology,2024,7(1).
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| APA |
Zhao，Yu.,Yang，Mengqi.,Gong，Fanglei.,Pan，Yuqi.,Hu，Minghui.,...&Sun，Kun.(2024).Accelerating 3D genomics data analysis with Microcket.Communications Biology,7(1).
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| MLA |
Zhao，Yu,et al."Accelerating 3D genomics data analysis with Microcket".Communications Biology 7.1(2024).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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