| 题名 | Generalizable transcriptome-based tumor malignant level evaluation and molecular subtyping towards precision oncology |
| 作者 | |
| 通讯作者 | Xia，Zhaohua; Zhao，Xin; Sun，Kun |
| 发表日期 | 2024-12-01
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| DOI | |
| 发表期刊 | |
| EISSN | 1479-5876
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| 卷号 | 22期号:1 |
| 摘要 | In cancer treatment, therapeutic strategies that integrate tumor-specific characteristics (i.e., precision oncology) are widely implemented to provide clinical benefits for cancer patients. Here, through in-depth integration of tumor transcriptome and patients’ prognoses across cancers, we investigated dysregulated and prognosis-associated genes and catalogued such important genes in a cancer type-dependent manner. Utilizing the expression matrices of these genes, we built models to quantitatively evaluate the malignant levels of tumors across cancers, which could add value to the clinical staging system for improved prediction of patients’ survival. Furthermore, we performed a transcriptome-based molecular subtyping on hepatocellular carcinoma, which revealed three subtypes with significantly diversified clinical outcomes, mutation landscapes, immune microenvironment, and dysregulated pathways. As tumor transcriptome was commonly profiled in clinical practice with low experimental complexity and cost, this work proposed easy-to-perform approaches for practical clinical promotion towards better healthcare and precision oncology of cancer patients. |
| 关键词 | |
| 相关链接 | [Scopus记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 通讯
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| Scopus记录号 | 2-s2.0-85194879233
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| 来源库 | Scopus
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| 引用统计 | |
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/778536 |
| 专题 | 南方科技大学第二附属医院 生命科学学院 南方科技大学医学院 生命科学学院_生物系 南方科技大学医学院_生物化学系 |
| 作者单位 | 1.Institute of Cancer Research,Shenzhen Bay Laboratory,Shenzhen,518132,China 2.Hepato-Biliary Surgery Division,The Second Affiliated Hospital,Shenzhen Third People’s Hospital,Southern University of Science and Technology,Shenzhen,518100,China 3.Department of Biology,Southern University of Science and Technology,Shenzhen,518055,China 4.Thoracic Surgical Department,Shenzhen Third People’s Hospital,The Second Affiliated Hospital,Southern University of Science and Technology,Shenzhen,518100,China 5.Department of Biochemistry,School of Medicine,Southern University of Science and Technology,Shenzhen,518055,China 6.Molecular Cancer Research Center,School of Medicine,Shenzhen Campus of Sun Yat-sen University,Sun Yat-sen University,Shenzhen,518107,China 7.Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei,230027,China 8.Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation,Guangdong-Hong Kong Joint Laboratory for RNA Medicine,Medical Research Center,Sun Yat- Sen Memorial Hospital,Sun Yat-Sen University,Guangzhou,510120,China 9.Beijing Tsinghua Changgung Hospital,Tsinghua University School of Medicine,Beijing,102218,China 10.Integrative Microecology Clinical Center,Shenzhen Key Laboratory of Gastrointestinal Microbiota and Disease,Shenzhen Clinical Research Center for Digestive Disease,Shenzhen Technology Research Center of Gut Microbiota Transplantation,Shenzhen Hospital,Southern Medical University,Shenzhen,510086,China |
| 通讯作者单位 | 南方科技大学第二附属医院 |
| 推荐引用方式 GB/T 7714 |
Hu，Dingxue,Zhang，Ziteng,Liu，Xiaoyi,et al. Generalizable transcriptome-based tumor malignant level evaluation and molecular subtyping towards precision oncology[J]. Journal of Translational Medicine,2024,22(1).
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| APA |
Hu，Dingxue.,Zhang，Ziteng.,Liu，Xiaoyi.,Wu，Youchun.,An，Yunyun.,...&Sun，Kun.(2024).Generalizable transcriptome-based tumor malignant level evaluation and molecular subtyping towards precision oncology.Journal of Translational Medicine,22(1).
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| MLA |
Hu，Dingxue,et al."Generalizable transcriptome-based tumor malignant level evaluation and molecular subtyping towards precision oncology".Journal of Translational Medicine 22.1(2024).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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