南方科技大学知识苑(SUSTech KC): LncRNA RP11-818O24.3 promotes hair-follicle recovery via FGF2-PI3K/Akt signal pathway

题名	LncRNA RP11-818O24.3 promotes hair-follicle recovery via FGF2-PI3K/Akt signal pathway
作者	Bao，Linlin 1,2; Sun，Zhaojun 1,2; Dang，Lin 1,2; Zhang，Qianqian 1,2; Zheng，Lixiong 1,2; Yang，Fang1,2 ; Zhang，Jianglin 1,2
通讯作者	Yang，Fang
发表日期	2024-08-01
DOI	10.1007/s10616-024-00624-3
发表期刊	Cytotechnology 影响因子和分区
ISSN	0920-9069
EISSN	1573-0778
卷号	76 期号:4页码:425-439
摘要	A previous study indicated that patients with androgenic alopecia (AGA) have significantly reduced levels of LncRNA RP11-818O24.3. This study investigates whether LncRNA RP11-818O24.3 promotes hair-follicle recovery and its possible mechanism. Hair alteration and cutaneous histopathological changes induced by testosterone propionate were observed by H&E and bromodeoxyuridinc (BrdU) stain to evaluate the therapeutic effect of LncRNA RP11-818O24.3 in C57BL/6 J mice. The cellular viability was analyzed in LncRNA RP11-818O24.3-transfected human hair-follicle stem cells (HFSCs) in vitro. The signaling pathways and pro-proliferative factors were investigated by transcriptomic gene sequencing and qRT-PCR. LncRNA RP11-818O24.3 transfection successfully recovered hair growth and hair-follicle cells in AGA mice. In a series of HFSC studies in vitro, LncRNA RP11-818O24.3 transfection greatly promoted cellular proliferation and decreased cellular apoptosis. Transcriptome gene sequencing suggested that the phosphatidylinositol 3-kinase (PI3K)-Akt pathway was upregulated by LncRNA RP11-818O24.3. The qRT-PCR results showed that fibroblast growth factor (FGF)-2 was 14-times upregulated after LncRNA RP11-818O24.3 transfection. Hair-follicle recovery activity of LncRNA RP11-818O24.3 may involve the upregulation of FGF2 and PI3K-Akt to promote follicle stem cell survival. These data not only provide a theoretical basis for AGA development but also reveal a novel therapeutic method for AGA patients.
关键词	Androgenic alopecia Fibroblast growth factor 2 Human hair-follicle stem cells lncRNA PI3K/Akt pathway
相关链接	[Scopus记录]
收录类别	SCI ; EI
语种	英语
学校署名	第一 ; 通讯
ESI学科分类	BIOLOGY & BIOCHEMISTRY
Scopus记录号	2-s2.0-85193507957
来源库	Scopus
引用统计	被引频次[WOS]：1
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/778644
专题	南方科技大学第一附属医院
作者单位	1.Department of Dermatology,Shenzhen People’s Hospital (The Second Clinical Medical College,Jinan University; The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,No. 1017, Dongmen North Road, Luohu District, Guangdong,518020,China 2.Candidate Branch of National Clinical Research Center for Skin Diseases,Shenzhen,Guangdong,518020,China
第一作者单位	南方科技大学第一附属医院
通讯作者单位	南方科技大学第一附属医院
第一作者的第一单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Bao，Linlin,Sun，Zhaojun,Dang，Lin,et al. LncRNA RP11-818O24.3 promotes hair-follicle recovery via FGF2-PI3K/Akt signal pathway[J]. Cytotechnology,2024,76(4):425-439.
APA	Bao，Linlin.,Sun，Zhaojun.,Dang，Lin.,Zhang，Qianqian.,Zheng，Lixiong.,...&Zhang，Jianglin.(2024).LncRNA RP11-818O24.3 promotes hair-follicle recovery via FGF2-PI3K/Akt signal pathway.Cytotechnology,76(4),425-439.
MLA	Bao，Linlin,et al."LncRNA RP11-818O24.3 promotes hair-follicle recovery via FGF2-PI3K/Akt signal pathway".Cytotechnology 76.4(2024):425-439.