题名 | Paeoniflorigenone inhibits ovarian cancer metastasis through targeting the MUC1/Wnt/β‑catenin pathway |
作者 | |
通讯作者 | Xu,Ye |
发表日期 | 2024-07-01
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DOI | |
发表期刊 | |
ISSN | 1107-3756
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EISSN | 1791-244X
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卷号 | 54期号:1 |
摘要 | Ovarian cancer (Oc) is one of the most common gynecological malignancies. currently, chemoradiotherapy is the primary clinical treatment approach for Oc; however, it has severe side effects and a high rate of recurrence. Thus, there is an urgent need to develop innovative therapeutic options. Paeoniflorigenone (PFG) is a monoterpene compound isolated from the traditional chinese medicine Paeoniae Radix Rubra. PFG can inhibit the proliferation of tumor cells; however, its anticancer activity against Oc has yet to be elucidated. Mucin 1 (MUc1) is highly expressed in various malignant tumors, and is associated with tumor proliferation, metastasis and epithelial‑mesenchymal transition (EMT). In addition, MUc1 affects numerous signaling pathways in tumor cells. In order to develop a possible treatment approach for metastatic OC, the antitumor activity of PFG in OC cells was investigated using Cell Counting Kit‑8 assay, Edu assay, flow cytometry, Transwell assay and western blot analysis. In addition, it was assessed how PFG affects MUC1 expression and function. The experiments revealed that PFG significantly inhibited OC cell proliferation, migration, invasion and EMT. PFG also induced S‑phase cell cycle arrest in OC cells. Furthermore, PFG inhibited MUc1 promoter activity, which led to a decrease in MUc1 protein expression. By contrast, MUc1 promoted Oc progression, including cell proliferation, cell cycle progres‑ sion and cell migration. Stable knockdown of MUc1 in Oc cells improved the ability of PFG to block the Wnt/β‑catenin pathway, and to limit tumor cell invasion and migration, whereas MUc1 overexpression partially counteracted the antitumor effects of PFG. In conclusion, the present study demonstrated that PFG may inhibit the MUC1/Wnt/β‑catenin pathway to induce anti‑metastatic, anti‑invasive and anti‑EMT effects on OC. Notably, MUC1 may be a direct target of PFG. Thus, PFG holds promise as a specific antitumor agent for the treatment of Oc. |
关键词 | |
相关链接 | [Scopus记录] |
收录类别 | |
语种 | 英语
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学校署名 | 其他
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ESI学科分类 | CLINICAL MEDICINE
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Scopus记录号 | 2-s2.0-85194125513
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来源库 | Scopus
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引用统计 | |
成果类型 | 期刊论文 |
条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/778666 |
专题 | 南方科技大学医学院_人类细胞生物和遗传学系 南方科技大学医学院 |
作者单位 | 1.Department of Immunology and Microbiology,School of Basic Medical Sciences,Zhejiang chinese Medical University,Hangzhou,Zhejiang,310053,China 2.Department of Human Cell Biology and Genetics,School of Medicine,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China |
推荐引用方式 GB/T 7714 |
Liu,Qingling,Jiang,Liqin,Zhao,Yun,等. Paeoniflorigenone inhibits ovarian cancer metastasis through targeting the MUC1/Wnt/β‑catenin pathway[J]. International Journal of Molecular Medicine,2024,54(1).
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APA |
Liu,Qingling.,Jiang,Liqin.,Zhao,Yun.,Su,Fang.,Li,Junfeng.,...&Tao,Fangfang.(2024).Paeoniflorigenone inhibits ovarian cancer metastasis through targeting the MUC1/Wnt/β‑catenin pathway.International Journal of Molecular Medicine,54(1).
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MLA |
Liu,Qingling,et al."Paeoniflorigenone inhibits ovarian cancer metastasis through targeting the MUC1/Wnt/β‑catenin pathway".International Journal of Molecular Medicine 54.1(2024).
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