南方科技大学知识苑(SUSTech KC): SP6 controls human cytotrophoblast fate decisions and trophoblast stem cell establishment by targeting MSX2 regulatory elements

题名	SP6 controls human cytotrophoblast fate decisions and trophoblast stem cell establishment by targeting MSX2 regulatory elements
作者	Chen，Yanglin 1; Ye，Xianhua 1; Zhong，Yulong 1; Kang，Xiangjin 2; Tang，Yanqing 1; Zhu，Haoyun 1; Pang，Changmiao 1; Ning，Shaoqiang 1; Liang，Shiqing 1; Zhang，Feifan 1; Li，Chao 1; Li，Jie 1; Gu，Chengtao 1; Cheng，Yuanxiong 3; Kuang，Zhanpeng 4; Qiu，Jingyang 5; Jin，Jin 6; Luo，Haisi 6; Fu，Mingyu 1; Hui，Hannah Xiaoyan 7; Li，Lei 2,8; Ruan，Degong 9; Liu，Pentao 9; Chen，Xi10 ; Sun，Liangzhong 4; Ai，Shanshan 1; Gao，Xuefei 1,3,4
通讯作者	Sun，Liangzhong; Ai，Shanshan; Gao，Xuefei
发表日期	2024-06-17
DOI	10.1016/j.devcel.2024.03.025
发表期刊	Developmental Cell 影响因子和分区
ISSN	1534-5807
EISSN	1878-1551
卷号	59 期号:12页码:1506-1522.e11
摘要	The commitment and differentiation of human placental progenitor cytotrophoblast (CT) cells are crucial for a successful pregnancy, but the underlying mechanism remains poorly understood. Here, we identified the transcription factor (TF), specificity protein 6 (SP6), as a human species-specific trophoblast lineage TF expressed in human placental CT cells. Using pluripotent stem cells as a model, we demonstrated that SP6 controls CT generation and the establishment of trophoblast stem cells (TSCs) and identified msh homeobox 2 (MSX2) as the downstream effector in these events. Mechanistically, we showed that SP6 interacts with histone acetyltransferase P300 to alter the landscape of H3K27ac at targeted regulatory elements, thereby favoring transcriptional activation and facilitating CT cell fate decisions and TSC maintenance. Our results established SP6 as a regulator of the human trophoblast lineage and implied its role in placental development and the pathogenies of placental diseases.
关键词	Cytotrophoblast Fate Decision Human Species-specific MSX2 Placental Progenitor Specificity Protein 6 Transcription Factor Trophoblast Lineage Trophoblast Stem Cell
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
学校署名	其他
ESI学科分类	MOLECULAR BIOLOGY & GENETICS
Scopus记录号	2-s2.0-85189657766
来源库	Scopus
引用统计
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/778710
专题	生命科学学院生命科学学院_系统生物学系
作者单位	1.Guangdong Provincial Key Laboratory of Bone and Joint Degenerative Diseases,Department of Physiology,School of Basic Medical Sciences,Southern Medical University,Guangzhou,510515,China 2.Department of Obstetrics and Gynecology,Center for Reproductive Medicine,Guangdong Provincial Key Laboratory of Major Obstetric Diseases,The Third Affiliated Hospital of Guangzhou Medical University,Guangzhou,510150,China 3.Department of Respiratory and Critical Care Medicine,The Third Affiliated Hospital,Southern Medical University,Guangzhou,Guangdong,510630,China 4.Department of Pediatrics,Nanfang Hospital,Southern Medical University,Guangzhou,510515,China 5.Department of Cell Biology,School of Basic Medical Sciences,Southern Medical University,Guangzhou,510515,China 6.Department of Gynaecology and Obstetrics,Nanfang Hospital,Southern Medical University,Guangzhou,510515,China 7.School of Biomedical Sciences,The Chinese University of Hong Kong,Hong Kong,999077,Hong Kong 8.Key Laboratory for Reproductive Medicine of Guangdong Province,The Third Affiliated Hospital of Guangzhou Medical University,Guangzhou,510515,China 9.School of Biomedical Sciences,Stem Cell,and Regenerative Medicine Consortium,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong,999077,Hong Kong 10.Shenzhen Key Laboratory of Gene Regulation and Systems Biology,School of Life Sciences,Southern University of Science and Technology,Shenzhen,518055,China
推荐引用方式 GB/T 7714	Chen，Yanglin,Ye，Xianhua,Zhong，Yulong,et al. SP6 controls human cytotrophoblast fate decisions and trophoblast stem cell establishment by targeting MSX2 regulatory elements[J]. Developmental Cell,2024,59(12):1506-1522.e11.
APA	Chen，Yanglin.,Ye，Xianhua.,Zhong，Yulong.,Kang，Xiangjin.,Tang，Yanqing.,...&Gao，Xuefei.(2024).SP6 controls human cytotrophoblast fate decisions and trophoblast stem cell establishment by targeting MSX2 regulatory elements.Developmental Cell,59(12),1506-1522.e11.
MLA	Chen，Yanglin,et al."SP6 controls human cytotrophoblast fate decisions and trophoblast stem cell establishment by targeting MSX2 regulatory elements".Developmental Cell 59.12(2024):1506-1522.e11.