A FUNCTIONAL STUDY OF THE PARABRACHIAL PDYN-EXPRESSING NEURONS IN MICE

体温调节对哺乳动物的生存至关重要，即关乎产热和散热之间的平衡，从而 维持生理上有利的核心体温，让动物更好地适应寒冷或炎热的外部环境。在野生 型小鼠中，中枢神经系统当中的外侧臂旁核已被确定为输入温度相关信息的关键 脑区，该脑区会把这些信息传递到位于下丘脑视前区的体温调节中枢。在我们的 研究中，通过钙信号光纤记录法，我们在小鼠外侧臂旁核中发现负责热防御机制 的且向视前区投射的强啡肽原 (Pdyn) 阳性神经元，同时对多种类型的刺激做出 响应，包括非痛的冷和热刺激以及产生痛觉的冷、热和机械力刺激。此外，利用 化学遗传学抑制外侧臂旁核 Pdyn 阳性神经元，导致了 Pdyn-Cre 小鼠核心体温升 高且其恢复正常所需时间延长的现象。这可能暗示外侧臂旁核 Pdyn 阳性神经元 参与了调节压力引起的体温变化的过程，其中机制有待进一步研究。总的来说， 我们的研究揭示了外侧臂旁核 Pdyn 阳性神经元的功能不仅能在热环境下维持个 体的核心体温稳态，而且可能参与了压力诱发的体温调节。

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