葡萄糖作为磁共振探针材料及其代谢成像研究

葡萄糖作为一种重要的单糖，不仅在人体能量的供应中发挥着至关重
要的作用，而且也是维持机体正常生理功能的必需物质。在一系列复杂的
生化过程中，葡萄糖可被转化为糖原储存在肝脏和肌肉中。将葡萄糖、糖
原作为探针应用于医学成像技术具有巨大的潜力。对葡萄糖、糖原进行成
像可以揭示其分布和代谢动态，以及在病理状态下的异常积累，为疾病诊
断和治疗提供了关键的生物标志物信息。现有的葡萄糖及糖原成像方法包
括正电子发射断层成像、光学成像、磁共振成像， 这些技术能够以非侵入
性的方式提供有关葡萄糖和糖原代谢状态的信息，然而这些方法具有各自
的局限性，多数方法难以在人体上应用。
本文发展了一种基于中继核奥式效应（rNOE）的人体糖原磁共振成像
方法（glycoNOE），应用于人体肌糖原代谢成像研究。首先通过体外实验，
分析并建立了glycoNOE 信号与糖原浓度的定量关系，接着在33 名健康受
试者的小腿上进行了glycoNOE 的验证，得到肌糖原浓度为92±5mM，符
合预期。此外，为了探究葡萄糖对人小腿运动后糖原消耗及补充的影响，
本研究在23 名空腹受试者进行规定方案运动前后人体肌糖原的变化情况，
并选择其中五名受试者在运动后摄入葡萄糖饮品。结果表明，高强度运动
的肌肉产生了三种类型的糖原消耗补充情况，且摄入葡萄糖可以促进这一
过程。本文的研究结果对于高灵敏度无创检测人体糖原提供了新角度，并
提供了潜在的优化运动表现方法。

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