中文版 | English
题名

缓氧联合抗炎的新方法用于类风湿关节炎协同治疗

其他题名
A NOVEL METHOD OF ALLEVIATE HYPOXIA COMBINED WITH ANTI-INFLAMMATORY FOR SYNERGISTIC TREATMENT IN RHEUMATOID ARTHRITIS
姓名
姓名拼音
TAN Jianwei
学号
12233345
学位类型
硕士
学位专业
0856 材料与化工
学科门类/专业学位类别
08 工学
导师
陈敬钦
导师单位
中国科学院深圳先进技术研究院
论文答辩日期
2024-05-06
论文提交日期
2024-07-11
学位授予单位
南方科技大学
学位授予地点
深圳
摘要
类风湿关节炎(Rheumatoid ArthritisRA)是一种常见的慢性、自身免疫性的炎症性关节疾病,主要表现为关节炎,即关节的炎症和疼痛。关节滑膜炎症是类风湿性关节炎最重要的病理特征之一,它主要是关节滑膜细胞的炎性增生和血管异常,从而导致软骨和骨头的损害。此外,炎症微环境中存在的乏氧状态也是类风湿关节炎病理过程的重要特征之一。乏氧状态会激活滑膜细胞和炎症细胞,促进炎症介质的释放和关节组织的破坏,从而加剧类风湿关节炎严重程度。目前的治疗药物存在药物副作用大、治疗机制单一 、制药成本高等缺点。 本研究旨在探究一种新型纳米材料CaO2@ZIF-67@MTX 的治疗效果,通过联合缓氧和抗炎协同靶向治疗类风湿关节炎。通过材料表征,本研究确认了该纳米材料的结构和物化性质。细胞实验结果表明,CaO2@ZIF-67@MTX 对炎症细胞的活性具有显著抑制作用,并且能改善细胞内乏氧环境。体内治疗实验进一步验证了该纳米材料在类风湿关节炎小鼠模型中具有显著的治疗效果,能够有效抑制关节肿胀并减轻关节损伤。生物安全性实验结果显示,CaO2@ZIF-67@MTX 对细胞和动物内脏组织无明显毒性和损伤。综合而言,CaO2@ZIF-67@MTX 作为一种缓氧联合抗炎的纳米材料,在类风湿关节炎协同治疗中展现出了良好的治疗效果和生物安全性,具有临床应用的潜力。
关键词
语种
中文
培养类别
独立培养
入学年份
2022
学位授予年份
2024-07
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谭键伟. 缓氧联合抗炎的新方法用于类风湿关节炎协同治疗[D]. 深圳. 南方科技大学,2024.
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