Advances in Noninvasive Molecular Imaging Probes for Liver Fibrosis Diagnosis

Chen, Shaofang1,2; Zhuang, Danping1,2; Jia, Qingyun1,2; Guo, Bing3; Hu, Genwen1,2

2024-07-01

10.34133/bmr.0042

BIOMATERIALS RESEARCH   影响因子和分区

1226-4601

2055-7124

Liver fibrosis is a wound-healing response to chronic liver injury, which may lead to cirrhosis and cancer. Early-stage fibrosis is reversible, and it is difficult to precisely diagnose with conventional imaging modalities such as magnetic resonance imaging, positron emission tomography, single-photon emission computed tomography, and ultrasound imaging. In contrast, probe-assisted molecular imaging offers a promising noninvasive approach to visualize early fibrosis changes in vivo, thus facilitating early diagnosis and staging liver fibrosis, and even monitoring of the treatment response. Here, the most recent progress in molecular imaging technologies for liver fibrosis is updated. We start by illustrating pathogenesis for liver fibrosis, which includes capillarization of liver sinusoidal endothelial cells, cellular and molecular processes involved in inflammation and fibrogenesis, as well as processes of collagen synthesis, oxidation, and crosslinking. Furthermore, the biological targets used in molecular imaging of liver fibrosis are summarized, which are composed of receptors on hepatic stellate cells, macrophages, and even liver collagen. Notably, the focus is on insights into the advances in imaging modalities developed for liver fibrosis diagnosis and the update in the corresponding contrast agents. In addition, challenges and opportunities for future research and clinical translation of the molecular imaging modalities and the contrast agents are pointed out. We hope that this review would serve as a guide for scientists and students who are interested in liver fibrosis imaging and treatment, and as well expedite the translation of molecular imaging technologies from bench to bedside.

SCI

英语

通讯

National Natural Science Foundation of China[82171893] ; Ministry of Education, China[HZKY20220312] ; Guangdong Basic and Applied Basic Research Foundation["2021A1515110086","2022A1515011781"] ; Shenzhen Key Laboratory of Advanced Functional Carbon Materials Research and Comprehensive Application[ZDSYS20220527171407017]

Engineering ; Materials Science

Engineering, Biomedical ; Materials Science, Biomaterials

WOS:001262577800001

AMER ASSOC ADVANCEMENT SCIENCE

Web of Science

1.Jinan Univ, Shenzhen Peoples Hosp, The Clin Med Coll 2, Dept Radiol, Shenzhen 518020, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
3.Harbin Inst Technol, Sch Sci, Shenzhen Key Lab Flexible Printed Elect Technol, Shenzhen Key Lab Adv Funct Carbon Mat Res & Compre, Shenzhen 518055, Peoples R China

Chen, Shaofang,Zhuang, Danping,Jia, Qingyun,et al. Advances in Noninvasive Molecular Imaging Probes for Liver Fibrosis Diagnosis[J]. BIOMATERIALS RESEARCH,2024,28.

Chen, Shaofang,Zhuang, Danping,Jia, Qingyun,Guo, Bing,&Hu, Genwen.(2024).Advances in Noninvasive Molecular Imaging Probes for Liver Fibrosis Diagnosis.BIOMATERIALS RESEARCH,28.

Chen, Shaofang,et al."Advances in Noninvasive Molecular Imaging Probes for Liver Fibrosis Diagnosis".BIOMATERIALS RESEARCH 28(2024).