Association of peripheral inflammatory indicators with osteoarthritis risk

Zhang, Shiyong1; Zhong, Yanlin1; Wang, Xudong1; Jiang, Wei2; Chen, Xicong3; Kang, Yunze1; Li, Zhiwen1; Liao, Weiming1; Zheng, Linli1; Sheng, Puyi1; Zhang, Ziji1

2024-09-01

10.1016/j.ocarto.2024.100496

OSTEOARTHRITIS AND CARTILAGE OPEN   影响因子和分区

2665-9131

Objectives: Numerous studies have established the role of inflammation in osteoarthritis (OA) progression, yet limited research explores the association between systemic inflammatory indicators and pre-diagnosis OA risk. This study aimed to investigate the association between peripheral inflammatory indicators and the risk of OA using data from the UK Biobank. Methods: The study analyzed data from 417,507 participants in the UK Biobank, including neutrophil count, lymphocyte count, monocyte count, platelet count, and C-reactive protein meter. Additionally, derived ratios such as NLR(neutrophils-lymphocytes ratio), PLR(Platelets-lymphocytes ratio), SII(systemic immune-inflammation index), and LMR (lymphocytes-monocytes ratio) were examined. Cox proportional hazards models and restricted cubic spline models were used to assess both linear and nonlinear associations. Results: Over a mean follow-up period of 12.7 years, a total of 49,509 OA events were identified. The findings revealed that CRP (HR:1.06, 95%CI:1.05-1.07), NLR (HR:1.02, 95%CI:1.01-1.03), PLR (HR:1.02, 95% CI:1.01-1.03), and SII (HR:1.03, 95%CI:1.01-1.04) were associated with an increased risk of OA, while LMR (HR:0.97, 95%CI:0.96-0.99) showed a significant negative correlation with OA risk. Subgroup analyses further emphasized that these associations were significant across most of the population. Although neutrophils, lymphocytes, monocytes, and platelets showed a nominal association with the risk of OA, the results were unreliable, especially for specific joint OA. Conclusion: The study provides evidence of a significant association between elevated peripheral inflammatory indicators and OA risk. These findings underscore the importance of low-grade chronic inflammation in OA development. The potential clinical utility of these indicators as early predictors of OA is suggested, warranting further exploration.

Osteoarthritis Peripheral inflammation UK biobank Prospective cohort Inflammatory indicators

ESCI

英语

其他

National Natural Science Foundation of China["82172406","82201719"] ; Natural Science Foundation of Guangdong Province[2022A1515012279] ; China Postdoctoral Science Foundation[2023M744059]

Orthopedics ; Rheumatology

Orthopedics ; Rheumatology

WOS:001259749500001

ELSEVIER

Web of Science

1.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Joint Surg, Guangzhou 510080, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Dept Bone & Joint,Clin Med Coll 2,Affiliated Hosp, Shenzhen 518020, Guangdong, Peoples R China
3.Foshan Hosp Tradit Chinese Med, Dept Orthoped 10, Foshan, Guangdong, Peoples R China

Zhang, Shiyong,Zhong, Yanlin,Wang, Xudong,et al. Association of peripheral inflammatory indicators with osteoarthritis risk[J]. OSTEOARTHRITIS AND CARTILAGE OPEN,2024,6(3).

Zhang, Shiyong.,Zhong, Yanlin.,Wang, Xudong.,Jiang, Wei.,Chen, Xicong.,...&Zhang, Ziji.(2024).Association of peripheral inflammatory indicators with osteoarthritis risk.OSTEOARTHRITIS AND CARTILAGE OPEN,6(3).

Zhang, Shiyong,et al."Association of peripheral inflammatory indicators with osteoarthritis risk".OSTEOARTHRITIS AND CARTILAGE OPEN 6.3(2024).