南方科技大学知识苑(SUSTech KC): The dynamic molecular characteristics of neutrophils are associated with disease progression in dengue patients

题名	The dynamic molecular characteristics of neutrophils are associated with disease progression in dengue patients
作者	Ou, Guanyong1,2 ; Liu, Jiexiang 3; Zou, Rongrong 1; Gu, Yuchen 1,2 ; Niu, Shiyu1,2 ; Yin, Juzhen1,2 ; Yuan, Jing 1 ; Qu, Zhijun 4; Yang, Yang 1 ; Liu, Yingxia 1
通讯作者	Qu, Zhijun; Yang, Yang; Liu, Yingxia
发表日期	2024-06-01
DOI	10.1002/jmv.29729
发表期刊	JOURNAL OF MEDICAL VIROLOGY 影响因子和分区
ISSN	0146-6615
EISSN	1096-9071
卷号	96 期号:6
摘要	Dengue, the most prevalent mosquito-borne disease worldwide, poses a significant health burden. This study integrates clinical data and transcriptomic datasets from different phases of dengue to investigate distinctive and shared cellular and molecular features. Clinical data from 29 dengue patients were collected and analyzed alongside a public transcriptomic data set (GSE28405) to perform differential gene expression analysis, functional enrichment, immune landscape assessment, and development of machine learning model. Neutropenia was observed in 54.79% of dengue patients, particularly during the defervescence phase (65.79%) in clinical cohorts. Bioinformatics analyses corroborated a significant reduction in neutrophil immune infiltration in dengue patients. Receiver operating characteristic curve analysis demonstrated that dynamic changes in neutrophil infiltration levels could predict disease progression, especially during the defervescence phase, with the area under the curve of 0.96. Three neutrophil-associated biomarkers-DHRS12, Transforming growth factor alpha, and ZDHHC19-were identified as promising for diagnosing and predicting dengue progression. In addition, the activation of neutrophil extracellular traps was significantly enhanced and linked to Fc gamma R-mediated signaling pathways and Toll-like receptor signaling pathways. Neutrophil activation and depletion play a critical role in dengue's immune response. The identified biomarkers and their associated pathways offer potential for improved diagnosis and understanding of dengue pathogenesis and progression.
关键词	bioinformatics biomarker dengue immune microenvironment machine learning neutrophil
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	National Key R&D Program of China["2023YFA0915600","2023YFC3041500","2021YFC2301803"] ; Shenzhen Medical Research Funding[D2301014]
WOS研究方向	Virology
WOS类目	Virology
WOS记录号	WOS:001256251900034
出版者	WILEY
ESI学科分类	MICROBIOLOGY
来源库	Web of Science
引用统计
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/786741
专题	南方科技大学第二附属医院南方科技大学医学院
作者单位	1.Southern Univ Sci & Technol, Peoples Hosp Shenzhen 3, Second Hosp, Shenzhen Key Lab Pathogen & Immun,Natl Clin Res Ct, 29 Bulan Rd, Shenzhen 518112, Peoples R China 2.Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China 3.Guangzhou Univ Chinese Med, Shenzhen Clin Med Coll, Shenzhen, Peoples R China 4.Longgang Cent Hosp Shenzhen, Shenzhen 518116, Guangdong, Peoples R China
第一作者单位	南方科技大学第二附属医院; 南方科技大学医学院
通讯作者单位	南方科技大学第二附属医院
第一作者的第一单位	南方科技大学第二附属医院
推荐引用方式 GB/T 7714	Ou, Guanyong,Liu, Jiexiang,Zou, Rongrong,et al. The dynamic molecular characteristics of neutrophils are associated with disease progression in dengue patients[J]. JOURNAL OF MEDICAL VIROLOGY,2024,96(6).
APA	Ou, Guanyong.,Liu, Jiexiang.,Zou, Rongrong.,Gu, Yuchen.,Niu, Shiyu.,...&Liu, Yingxia.(2024).The dynamic molecular characteristics of neutrophils are associated with disease progression in dengue patients.JOURNAL OF MEDICAL VIROLOGY,96(6).
MLA	Ou, Guanyong,et al."The dynamic molecular characteristics of neutrophils are associated with disease progression in dengue patients".JOURNAL OF MEDICAL VIROLOGY 96.6(2024).