| 题名 | Untargeted lipidomics of bronchopulmonary dysplasia induced by hyperoxia exposure in rats |
| 作者 | |
| 通讯作者 | Li, Yubai; Su, Qian |
| 发表日期 | 2024-05-01
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| DOI | |
| 发表期刊 | |
| ISSN | 2224-4336
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| EISSN | 2224-4344
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| 卷号 | 13期号:5 |
| 摘要 | Background: Bronchopulmonary dysplasia (BPD), characterized by impaired lung development, remains a leading cause of morbidity and mortality in premature infants. The synthesis and metabolism of lipids play a critical role in normal lung development, such as dipalmitoylphosphatidylcholine, a key component of pulmonary surfactant (PS). Therefore, we conducted a lipidomics study of rat lung tissue to explore the changes of pulmonary lipid composition in the progression of BPD disease. Methods: In this study, we exposed neonatal Sprague-Dawley (SD) rats to hyperoxia for 14 days. After hyperoxia exposure, the lung tissues of rats were analyzed pathologically, and untargeted lipidomics was analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Results: Hematoxylin-eosin (H&E) staining showed that the alveoli enlarged, the number of alveoli decreased and the pulmonary surfactant-associated protein D (SFTPD) decreased in hyperoxiaexposed rats. A total of 620 pulmonary lipids were detected by LC-MS/MS, covering 27 lipid categories. The most common lipids were triacylglycerol (TAG), followed by phosphatidylcholine (PC) and Conclusions: Compared with those rats exposed to normoxic conditions, the lipid levels in the lungs of rats exposed to hyperoxia for 14 days generally decreased, with the levels of TAG and PC decreasing most significantly. In short, our results provide a clue for finding therapeutic targets and biomarkers of a BPD rat model lung liposome. |
| 关键词 | |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 第一
; 通讯
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| 资助项目 | Shenzhen Science and Technology Program["JCYJ20220530152415031","JCYJ20220530152415034","JCYJ20230807112405011"]
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| WOS研究方向 | Pediatrics
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| WOS类目 | Pediatrics
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| WOS记录号 | WOS:001258134300005
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| 出版者 | |
| 来源库 | Web of Science
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| 引用统计 | |
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/786807 |
| 专题 | 南方科技大学第一附属医院 |
| 作者单位 | Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1,Dept Pediat,Div Neonatol, 1017 Dongmen North Rd, Shenzhen 518020, Peoples R China |
| 第一作者单位 | 南方科技大学第一附属医院 |
| 通讯作者单位 | 南方科技大学第一附属医院 |
| 第一作者的第一单位 | 南方科技大学第一附属医院 |
| 推荐引用方式 GB/T 7714 |
Li, Yubai,Su, Qian,Yan, Xudong,et al. Untargeted lipidomics of bronchopulmonary dysplasia induced by hyperoxia exposure in rats[J]. TRANSLATIONAL PEDIATRICS,2024,13(5).
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| APA |
Li, Yubai.,Su, Qian.,Yan, Xudong.,Qi, Jie.,Tu, Huiying.,...&Yu, Boshi.(2024).Untargeted lipidomics of bronchopulmonary dysplasia induced by hyperoxia exposure in rats.TRANSLATIONAL PEDIATRICS,13(5).
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| MLA |
Li, Yubai,et al."Untargeted lipidomics of bronchopulmonary dysplasia induced by hyperoxia exposure in rats".TRANSLATIONAL PEDIATRICS 13.5(2024).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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