Novel gelatin/ chitosan double network hydrogel reinforced by lignin and calcium silicate for potential treatment of bone defects

Cheng, Yuet1; Pan, Zheng2; Lin, Yuntao1; Chen, Yuling1; Li, Xiaolian1; Yang, Hongyu1; Shen, Yuehong1

2024-08-01

10.1016/j.polymertesting.2024.108507

POLYMER TESTING   影响因子和分区

0142-9418

1873-2348

Artificial materials for the potential treatment of bone defects are very trendy in such research fields. To investigate a hydrogel scaffold with better mechanical strength and osteoinductivity is always a challenge since brittle and soft properties are always the problems in traditional hydrogels. In our study, a novel gelatin/chitosan hydrogel crosslinked by a double network filled with lignin and calcium silicate is fabricated. Enhancements of mechanical strength, low swelling ratio, and improvement in osteoinductivity were achieved in this composite double network hydrogels. The results revealed that lignin was a key factor in raising the compressive strength and stability of the hydrogel because more hydrogen bonds were formed between lignin and the crosslinking network. Even after swelling equilibrium, the compressive strength remained almost unchanged. In addition, the hydrogel groups with a higher ratio of lignin also had lower cytotoxicity and improved osteoinductivity of preosteoblasts while the increasing concentration of calcium silicate progressively weakened these performances. Therefore, the gelatin/chitosan double network hydrogel reinforced by lignin would be a potential bone tissueengineered artificial material.

Gelatin Chitosan Lignin Calcium silicate Hydrogel

SCI ; EI

英语

其他

King Saud University, Riyadh, Saudi Arabia[RSP2024R267]

Materials Science ; Polymer Science

Materials Science, Characterization & Testing ; Polymer Science

WOS:001262526200001

ELSEVIER SCI LTD

20242716571342

Compressive strength ; Defects ; Hydrogels ; Hydrogen bonds ; Lignin ; Reinforcement ; Silicates ; Swelling

Colloid Chemistry:801.3 ; Physical Chemistry:801.4 ; Chemical Products Generally:804 ; Cellulose, Lignin and Derivatives:811.3 ; Materials Science:951

MATERIALS SCIENCE

Web of Science

1.Hong Kong Univ Sci & Technol, Peking Univ Shenzhen Hosp, Dept Oral & Maxillofacial Surg, Med Ctr,Shenzhen Peking Univ, Shenzhen 518035, Peoples R China
2.Southern Univ Sci & Technol, Dept Biomed Engn, Guangdong Prov Key Lab Adv Biomat, 1088 Xueyuan Ave, Shenzhen 518055, Guangdong, Peoples R China

Cheng, Yuet,Pan, Zheng,Lin, Yuntao,et al. Novel gelatin/ chitosan double network hydrogel reinforced by lignin and calcium silicate for potential treatment of bone defects[J]. POLYMER TESTING,2024,137.

Cheng, Yuet.,Pan, Zheng.,Lin, Yuntao.,Chen, Yuling.,Li, Xiaolian.,...&Shen, Yuehong.(2024).Novel gelatin/ chitosan double network hydrogel reinforced by lignin and calcium silicate for potential treatment of bone defects.POLYMER TESTING,137.

Cheng, Yuet,et al."Novel gelatin/ chitosan double network hydrogel reinforced by lignin and calcium silicate for potential treatment of bone defects".POLYMER TESTING 137(2024).