Receptor tyrosine kinase-like orphan receptor serves as a potential target in cancer immunotherapy

Wang, Jiaqi1; Li, Zhoufang2; Zhao, Qi1,3

2024-07-01

10.1093/jleuko/qiae141

JOURNAL OF LEUKOCYTE BIOLOGY   影响因子和分区

0741-5400

1938-3673

["Receptor tyrosine kinase-like orphan receptor (ROR), consisting of ROR1 and ROR2, is a conserved family of receptor tyrosine kinase superfamily that plays crucial roles during embryonic development with limited expression in adult normal tissues. However, it is overexpressed in a range of hematological malignancies and solid tumors and functions in cellular processes including cell survival, polarity, and migration, serving as a potential target in cancer immunotherapy. This review summarizes the expression and structure of ROR in developmental morphogenesis and its function in cancers associated with Wnt5a signaling and highlights the cancer immunotherapy strategies targeting ROR.","Receptor tyrosine kinase-like orphan receptor has emerged as a potential target in cancer immunotherapy which may be attributed to its unique tumor-specific expression pattern, and essential functions in tumorigenesis."]

antibody-drug conjugates (ADCs) cancer immunotherapy chimeric antigen receptor T cell (CAR-T) monoclonal antibodies (mAbs) receptor tyrosine kinase-like orphan receptors (ROR1 and ROR2)

SCI

英语

其他

National Key Research and Development Program of China[2019YFA0904400] ; Natural Science Foundation of Guangdong Province[2023A1515010549] ; Science and Technology Development Fund of Macau[FDCT/0009/2023/RIC] ; University of Macau["MYRG2022-00143-FHS","MYRG-GRG2023-00158-FHS-UMDF"]

Cell Biology ; Hematology ; Immunology

Cell Biology ; Hematology ; Immunology

WOS:001263866900001

OXFORD UNIV PRESS

IMMUNOLOGY

Web of Science

1.Univ Macau, Inst Translat Med, Fac Hlth Sci, Canc Ctr, Taipa 999078, Macau, Peoples R China
2.Southern Univ Sci & Technol, Core Res Facil, Shenzhen 518055, Peoples R China
3.Univ Macau, MoE Frontiers Sci Ctr Precis Oncol, Taipa 999078, Macau, Peoples R China

Wang, Jiaqi,Li, Zhoufang,Zhao, Qi. Receptor tyrosine kinase-like orphan receptor serves as a potential target in cancer immunotherapy[J]. JOURNAL OF LEUKOCYTE BIOLOGY,2024.

Wang, Jiaqi,Li, Zhoufang,&Zhao, Qi.(2024).Receptor tyrosine kinase-like orphan receptor serves as a potential target in cancer immunotherapy.JOURNAL OF LEUKOCYTE BIOLOGY.

Wang, Jiaqi,et al."Receptor tyrosine kinase-like orphan receptor serves as a potential target in cancer immunotherapy".JOURNAL OF LEUKOCYTE BIOLOGY (2024).