Acupuncture as adjunctive treatment for linezolid-induced peripheral neuropathy: a case series report

Mo, Yuping1; Nie, Fan2; Wu, Jiahui1,3; Li, Linna1; Zhu, Zhu2; Deng, Guofang4; Fu, Liang4

2024-06-21

10.3389/fneur.2024.1388544

FRONTIERS IN NEUROLOGY   影响因子和分区

1664-2295

Background The treatment of multidrug-resistant tuberculosis (MDR-TB) and pre-extensively drug-resistant tuberculosis (pre-XDR-TB) remains challenging due to the limited availability of effective drugs. Linezolid has emerged as a promising therapeutic option for these cases. However, its long-term use can lead to complications such as peripheral and optic neuropathies. Acupuncture, a cornerstone of traditional Chinese medicine, has been shown to be effective in the treatment of peripheral neuropathy (PN). This study examines the potential benefits of acupuncture in the treatment of linezolid-induced peripheral neuropathy (LIPN).Methods Four patients, aged 27 to 60 years, diagnosed with LIPN, underwent daily acupuncture treatments. The main endpoint was to assess the efficacy of acupuncture in reducing neuropathic pain associated with LIPN in patients. This was primarily measured using changes in the Short Form McGill Pain Questionnaire (SF-MPQ) scores before and after acupuncture treatment.Results Three of the patients experienced significant symptom remission, while one experienced marginal improvement. Treatments ranged from 7 to 18 sessions. Specifically, the first patient reported substantial relief with a score reduction from 33 to 13; the second patient observed minimal change; the third patient's score decreased dramatically from 10 to 2 after eight sessions; the last patient had a score reduction from 21 to 12 after five sessions, but did not continue treatment for a second assessment.Conclusion Acupuncture is a promising therapeutic approach for LIPN. However, larger and more thorough studies are needed to determine its full potential.

peripheral neuropathy acupuncture linezolid case report multidrug-resistant tuberculosis

SCI

英语

第一 ; 通讯

National Natural Science Foundation of China[82070016] ; National Key Research and Development Program of China["2023YFC2306700","2023YFC2306703"] ; Guangdong Provincial Clinical Research Center for Tuberculosis Project[2020B1111170014] ; Shenzhen High-level Hospital Construction Fund[XKJS-CRGRK-008] ; Shenzhen Clinical Research Center for Tuberculosis[20210617141509001] ; Shenzhen Scientific and Technological Foundation["KCXFZ20211020163545004","RCJC20221008092726022"] ; Shenzhen Third People's Hospital Research Fund["G2021010","G2021015","G2021023","G2022138","G2022155"]

Neurosciences & Neurology

Clinical Neurology ; Neurosciences

WOS:001262253400001

FRONTIERS MEDIA SA

Web of Science

1.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Natl Clin Res Ctr Infect Dis Shenzhen, Guangdong Prov Clin Res Ctr Infect Dis TB,Tradit C, Shenzhen, Peoples R China
2.Natl Clin Res Ctr Infect Dis Shenzhen, Shenzhen, Peoples R China
3.Guangzhou Univ Chinese Med, Guangzhou, Peoples R China
4.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Natl Clin Res Ctr Infect Dis Shenzhen, Guangdong Prov Clin Res Ctr Infect Dis TB,Pulm Dis, Shenzhen, Peoples R China

Mo, Yuping,Nie, Fan,Wu, Jiahui,et al. Acupuncture as adjunctive treatment for linezolid-induced peripheral neuropathy: a case series report[J]. FRONTIERS IN NEUROLOGY,2024,15.

Mo, Yuping.,Nie, Fan.,Wu, Jiahui.,Li, Linna.,Zhu, Zhu.,...&Fu, Liang.(2024).Acupuncture as adjunctive treatment for linezolid-induced peripheral neuropathy: a case series report.FRONTIERS IN NEUROLOGY,15.

Mo, Yuping,et al."Acupuncture as adjunctive treatment for linezolid-induced peripheral neuropathy: a case series report".FRONTIERS IN NEUROLOGY 15(2024).