Fluorescence imaging-guided surgery: current status and future directions

Ullah, Zia1; Roy, Shubham1; Muhammad, Saz1,2; Yu, Chen1,3; Huang, Haiyan1; Chen, Dongxiang1; Long, Haodong1; Yang, Xiulan4; Du, Xuelian5; Guo, Bing1

2024-06-01

10.1039/d4bm00410h

BIOMATERIALS SCIENCE   影响因子和分区

2047-4830

2047-4849

["Surgery is one of the most important paradigms for tumor therapy, while fluorescence imaging (FI) offers real-time intraoperative guidance, greatly boosting treatment prognosis. The imaging fidelity heavily relies on not only imaging facilities but also probes for imaging-guided surgery (IGS). So far, a great number of IGS probes with emission in visible (400-700 nm) and near-infrared (NIR 700-1700 nm) windows have been developed for pinpointing disease margins intraoperatively. Herein, the state-of-the-art fluorescent probes for IGS are timely updated, with a special focus on the fluorescent probes under clinical examination. For a better demonstration of the superiority of NIR FI over visible FI, both imaging modalities are critically compared regarding signal-to-background ratio, penetration depth, resolution, tissue autofluorescence, photostability, and biocompatibility. Various types of fluorescence IGS have been summarized to demonstrate its importance in the medical field. Furthermore, the most recent progress of fluorescent probes in NIR-I and NIR-II windows is summarized. Finally, an outlook on multimodal imaging, FI beyond NIR-II, efficient tumor targeting, automated IGS, the use of AI and machine learning for designing fluorescent probes, and the fluorescence-guided da Vinci surgical system is given. We hope this review will stimulate interest among researchers in different areas and expedite the translation of fluorescent probes from bench to bedside.","Illustrative representation of applications of fluorescence imaging-guided surgery in different types of cancers by utilizing different fluorescent probes."]

SCI ; EI

英语

其他

Chunhui Plan cooperative scientific research project of the Ministry of Education, China[HZKY20220312] ; Shenzhen Excellent Science and Technology Innovation Talents Training Project[RCBS20200714114910141] ; Special Foundation for General Basic Research Program of Shenzhen[JCYJ20210324132816039] ; Guangdong Basic and Applied Basic Research Foundation[2021A1515110086] ; General Project of Guangdong Natural Science Foundation[2022A1515011781] ; Shenzhen Key Laboratory of Advanced Functional Carbon Materials Research and Comprehensive Application[ZDSYS20220527171407017]

Materials Science

Materials Science, Biomaterials

WOS:001261735200001

ROYAL SOC CHEMISTRY

Web of Science

1.Harbin Inst Technol, Sch Sci, Shenzhen Key Lab Flexible Printed Elect Technol, Shenzhen Key Lab Adv Funct Carbon Mat Res & Compre, Shenzhen 518055, Peoples R China
2.Southern Univ Sci & Technol, Sch Syst Design & Intelligent Mfg, Shenzhen 518055, Peoples R China
3.Shenzhen Univ, Coll Chem & Environm Engn, Shenzhen 518060, Peoples R China
4.Yulin Normal Univ, Sch Comp Sci & Engn, Yulin 537000, Peoples R China
5.Guangzhou Univ Chinese Med, Shenzhen Tradit Chinese Med Hosp, Clin Med Coll 4, Dept Gynecol, 1 Fuhua Rd, Shenzhen 518033, Peoples R China

Ullah, Zia,Roy, Shubham,Muhammad, Saz,et al. Fluorescence imaging-guided surgery: current status and future directions[J]. BIOMATERIALS SCIENCE,2024.

Ullah, Zia.,Roy, Shubham.,Muhammad, Saz.,Yu, Chen.,Huang, Haiyan.,...&Guo, Bing.(2024).Fluorescence imaging-guided surgery: current status and future directions.BIOMATERIALS SCIENCE.

Ullah, Zia,et al."Fluorescence imaging-guided surgery: current status and future directions".BIOMATERIALS SCIENCE (2024).