Cellular Scale Curvature in Bioceramic Scaffolds Enhanced Bone Regeneration by Regulating Skeletal Stem Cells and Vascularization

Liu, Yang1,2; Wang, Yue3; Lin, Minmin1,2; Liu, Hongzhi1,2; Pan, Yonghao1,2; Wu, Jianqun4; Guo, Ziyu1,2; Li, Jiawei1,2; Yan, Bingtong1,2; Zhou, Hang1,2; Fan, Yuanhao1,2; Hu, Ganqing5; Liang, Haowen3; Zhang, Shibo3; Siu, Ming-Fung Francis6; Wu, Yongbo3; Bai, Jiaming3; Liu, Chao1

2024-07-01

10.1002/adhm.202401667

ADVANCED HEALTHCARE MATERIALS   影响因子和分区

2192-2640

2192-2659

["Critical-sized segmental bone defects cannot heal spontaneously, leading to disability and significant increase in mortality. However, current treatments utilizing bone grafts face a variety of challenges from donor availability to poor osseointegration. Drugs such as growth factors increase cancer risk and are very costly. Here, a porous bioceramic scaffold that promotes bone regeneration via solely mechanobiological design is reported. Two types of scaffolds with high versus low pore curvatures are created using high-precision 3D printing technology to fabricate pore curvatures radius in the 100s of micrometers. While both are able to support bone formation, the high-curvature pores induce higher ectopic bone formation and increased vessel invasion. Scaffolds with high-curvature pores also promote faster regeneration of critical-sized segmental bone defects by activating mechanosensitive pathways. High-curvature pore recruits skeletal stem cells and type H vessels from both the periosteum and the marrow during the early phase of repair. High-curvature pores have increased survival of transplanted GFP-labeled skeletal stem cells (SSCs) and recruit more host SSCs. Taken together, the bioceramic scaffolds with defined micrometer-scale pore curvatures demonstrate a mechanobiological approach for orthopedic scaffold design.","Critical-sized bone defects cannot heal on their own, leading to disability and death. Current treatments are costly and with significant side effects. This study introduces a porous bioceramic scaffold designed based on mechanobiological principles. High-curvature pores in the scaffold induce more bone formation, vessel invasion, and faster regeneration of bone defects by activating mechanosensitive pathways and recruiting skeletal stem cells. image"]

3D printing bioceramic bone scaffold mechanobiology skeletal stem cell

SCI ; EI

英语

第一 ; 通讯

Shenzhen Science and Technology Innovation Commission["KQTD20200820113012029","GJHZ20200731095606021","KQTD20190929172505711"] ; Guangdong Provincial Key Laboratory of Advanced Biomaterials[2022B1212010003] ; National Key R&D Program of China[2022YFE0197100]

Engineering ; Science & Technology - Other Topics ; Materials Science

Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials

WOS:001263655000001

WILEY

Web of Science

1.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Peoples R China
2.Southern Univ Sci & Technol, Guangdong Prov Key Lab Adv Biomat, Shenzhen 518055, Peoples R China
3.Southern Univ Sci & Technol, Dept Mech & Energy Engn, Shenzhen 518055, Peoples R China
4.Southern Univ Sci & Technol, Coll Med, Shenzhen 518055, Peoples R China
5.Cornell Univ, Dept Biomed Engn, Ithaca, NY 14850 USA
6.Hong Kong Polytech Univ, Dept Bldg & Real Estate, Hung Hom, Kowloon, Hong Kong 999077, Peoples R China

Liu, Yang,Wang, Yue,Lin, Minmin,et al. Cellular Scale Curvature in Bioceramic Scaffolds Enhanced Bone Regeneration by Regulating Skeletal Stem Cells and Vascularization[J]. ADVANCED HEALTHCARE MATERIALS,2024.

Liu, Yang.,Wang, Yue.,Lin, Minmin.,Liu, Hongzhi.,Pan, Yonghao.,...&Liu, Chao.(2024).Cellular Scale Curvature in Bioceramic Scaffolds Enhanced Bone Regeneration by Regulating Skeletal Stem Cells and Vascularization.ADVANCED HEALTHCARE MATERIALS.

Liu, Yang,et al."Cellular Scale Curvature in Bioceramic Scaffolds Enhanced Bone Regeneration by Regulating Skeletal Stem Cells and Vascularization".ADVANCED HEALTHCARE MATERIALS (2024).