A Superparamagnetic Composite Hydrogel Scaffold as In Vivo Dynamic Monitorable Theranostic Platform for Osteoarthritis Regeneration

Rong, Mayifei1; Liu, Dingge2; Xu, Xiaoguang1; Li, Ang3; Bai, Yihua1; Yang, Gang2; Liu, Kaiping2; Zhang, Zhihua2; Wang, Langran2; Wang, Kai4; Lu, Liying5; Jiang, Yong1; Liu, Ji6; Zhang, Xin2

2024-07-01

10.1002/adma.202405641

ADVANCED MATERIALS   影响因子和分区

0935-9648

1521-4095

["Osteoarthritis (OA) is a prevalent disease, characterized by subchondral fractures in its initial stages, which has no precise and specific treatment now. Here, a novel multifunctional scaffold is synthesized by photopolymerizing glycidyl methacrylate-modified hyaluronic acid (GMHA) as the matrix in the presence of hollow porous magnetic microspheres based on hydroxyapatite. In vivo subchondral bone repairing results demonstrate that the scaffold's meticulous design has most suitable properties for subchondral bone repair. The porous structure of inorganic particles within the scaffold facilitates efficient transport of loaded exogenous vascular endothelial growth factor (VEGF). The Fe3O4 nanoparticles assembled in microspheres promote the osteogenic differentiation of bone marrow mesenchymal stem cells and accelerate the new bone generation. These features enable the scaffold to exhibit favorable subchondral bone repair properties and attain high cartilage repair scores. The therapy results prove that the subchondral bone support considerably influences the upper cartilage repair process. Furthermore, magnetic resonance imaging monitoring demonstrates that Fe3O4 nanoparticles, which are gradually replaced by new bone during osteochondral defect repair, allow a noninvasive and radiation-free assessment to track the newborn bone during the OA repair process. The composite hydrogel scaffold (CHS) provides a versatile platform for biomedical applications in OA treatment.","A theranostic material, composite hydrogel scaffold (CHS), is synthesized based on glycidyl methacrylate modified hyaluronic acid (GMHA) and hollow porous magnetic hydroxyapatite-Fe3O4 microspheres. The vascular endothelial growth factor (VEGF)-loaded CHS exhibits subchondral bone repair function and achieves high cartilage repair scores. Its process can dynamically monitor using MRI. The CHS provides a versatile platform for osteoarthritis (OA) treatment. image"]

composite scaffolds hydrogel osteoarthritis superparamagnetic particles tissue engineering

SCI ; EI

英语

通讯

National Key Research and Development Program of China[2022YFA1204004] ; Beijing Nova Program[20220484180] ; National Natural Science Foundation of China["82172447","U23A20548"] ; Key Research and Development Program of Shaanxi[2023-YBSF-326] ; Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park[Z22111000740000]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:001263135000001

WILEY-V C H VERLAG GMBH

MATERIALS SCIENCE

Web of Science

1.Univ Sci & Technol Beijing, Sch Mat Sci & Engn, Beijing 100083, Peoples R China
2.Peking Univ Third Hosp, Inst Sports Med, Beijing Key Lab Sports Injuries, Beijing 100191, Peoples R China
3.Beijing Univ Technol, Fac Mat & Mfg, Beijing Key Lab Microstruct & Properties Adv Mat, Beijing 100124, Peoples R China
4.Handan Univ, Sch Math & Phys, Handan 056005, Peoples R China
5.Univ Sci & Technol Beijing, Sch Chem & Biol Engn, Beijing 100083, Peoples R China
6.Southern Univ Sci & Technol, Dept Mech & Energy Engn, Shenzhen 518055, Peoples R China

Rong, Mayifei,Liu, Dingge,Xu, Xiaoguang,et al. A Superparamagnetic Composite Hydrogel Scaffold as In Vivo Dynamic Monitorable Theranostic Platform for Osteoarthritis Regeneration[J]. ADVANCED MATERIALS,2024.

Rong, Mayifei.,Liu, Dingge.,Xu, Xiaoguang.,Li, Ang.,Bai, Yihua.,...&Zhang, Xin.(2024).A Superparamagnetic Composite Hydrogel Scaffold as In Vivo Dynamic Monitorable Theranostic Platform for Osteoarthritis Regeneration.ADVANCED MATERIALS.

Rong, Mayifei,et al."A Superparamagnetic Composite Hydrogel Scaffold as In Vivo Dynamic Monitorable Theranostic Platform for Osteoarthritis Regeneration".ADVANCED MATERIALS (2024).