Assessment of Oxygen Saturation in Breast Lesions Using Photoacoustic Imaging: Correlation With Benign and Malignant Disease

Huang, Zhibin1; Tian, Hongtian2,3; Luo, Hui2,3; Yang, Keen2,3; Chen, Jing2,3; Li, Guoqiu1,2,3; Ding, Zhimin2,3; Luo, Yuwei3,4,5; Tang, Shuzhen2,3; Xu, Jinfeng1,2,3; Wu, Huaiyu1,2,3; Dong, Fajin1,2,3

2024-06-01

10.1016/j.clbc.2024.01.006

CLINICAL BREAST CANCER   影响因子和分区

1526-8209

1938-0666

Exploring hypoxia in breast cancer, this study uses Photoacoustic (PA) and Ultrasound (US) imaging to assess oxygen saturation (So(2)) in 120 breast lesions. It differentiates malignant from benign lesions with improved accuracy using So(2) levels, revealing PA/US imaging's diagnostic superiority over traditional gray-scale US. These results highlight PA imaging's potential in enhancing breast cancer diagnosis. Background: Hypoxia is a hallmark of breast cancer (BC). Photoacoustic (PA) imaging, based on the use of laser-generated ultrasound (US), can detect oxygen saturation (So(2)) in the tissues of breast lesion patients. Purpose: To measure the oxygenation status of tissue in and on both sides of the lesion in breast lesion participants using a multimodal Photoacoustic/ultrasound (PA/US) imaging system and to determine the correlation between So(2) measured by PA imaging and benign or malignant disease. Materials and methods: Multimodal PA/US imaging and gray-scale US (GSUS) of breast lesion was performed in consecutive breast lesion participants imaged in the US Outpatient Clinic between 2022 and 2023. Dual-wavelength PA imaging was used to measure the So(2) value inside the lesion and on both sides of the tissue, and to distinguish benign from malignant lesions based on the So(2) value. The ability of So(2) to distinguish benign from malignant breast lesions was evaluated by the receiver operating characteristic curve (ROC) and the De-Long test. Results: A total of 120 breast lesion participants (median age, 42.5 years) were included in the study. The malignant lesions exhibited lower So(2) levels compared to benign lesions (malignant: 71.30%; benign: 83.81%; P < .01). Moreover, PA/US imaging demonstrates superior diagnostic results compared to GSUS, with an area under the curve (AUC) of 0.89 versus 0.70, sensitivity of 89.58% versus 85.42%, and specificity of 86.11% versus 55.56% at the So(2) cut-off value of 78.85 (P < .001). The false positive rate in GSUS reduced by 30.75%, and the false negative rate diminished by 4.16% with PA /US diagnosis. Finally, the So(2) on both sides tissues of malignant lesions are lower than that of benign lesions (P < .01). Conclusion: PA imaging allows for the assessment of So(2) within the lesions of breast lesion patients, thereby facilitating a superior distinction between benign and malignant lesions.

Breast Cancer Photoacoustic/Ultrasound Imaging Diagnostic Efficacy

SCI

英语

通讯

National Key R&D Program of China["2023YFC2411700","2023YFC2411705"] ; Clini- cal Scientist Training Program of Shenzhen People's Hospital[SYWGSCGZH202202]

Oncology

Oncology

WOS:001252681900001

CIG MEDIA GROUP, LP

Web of Science

1.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Ultrasound, Shenzhen 518020, Peoples R China
2.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Ultrasound, Shenzhen 518020, Guangdong, Peoples R China
3.Southern Univ Sci & Technol, Affiliated Hosp 1, 1017 Dongmen North Rd, Shenzhen 518020, Guangdong, Peoples R China
4.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Breast Surg, Shenzhen 518020, Guangdong, Peoples R China
5.ShenZhen Peoples Hosp, Dept Gen Surg, Shenzhen, Guangdong, Peoples R China

Huang, Zhibin,Tian, Hongtian,Luo, Hui,et al. Assessment of Oxygen Saturation in Breast Lesions Using Photoacoustic Imaging: Correlation With Benign and Malignant Disease[J]. CLINICAL BREAST CANCER,2024,24(4).

Huang, Zhibin.,Tian, Hongtian.,Luo, Hui.,Yang, Keen.,Chen, Jing.,...&Dong, Fajin.(2024).Assessment of Oxygen Saturation in Breast Lesions Using Photoacoustic Imaging: Correlation With Benign and Malignant Disease.CLINICAL BREAST CANCER,24(4).

Huang, Zhibin,et al."Assessment of Oxygen Saturation in Breast Lesions Using Photoacoustic Imaging: Correlation With Benign and Malignant Disease".CLINICAL BREAST CANCER 24.4(2024).