An Injectable Hydrogel with Ultrahigh Burst Pressure and Innate Antibacterial Activity for Emergency Hemostasis and Wound Repair

Yang, Yu1; He, Gang1; Pan, Zheng1; Zhang, Kaiwen1; Xian, Yiwen1; Zhu, Ziran1; Hong, Yonglong2; Zhang, Chong1; Wu, Decheng1

2024-06-01

10.1002/adma.202404811

ADVANCED MATERIALS   影响因子和分区

0935-9648

1521-4095

["Uncontrolled bleeding and wound infections following severe trauma pose significant challenges for existing tissue adhesives, primarily due to their weak wet adhesion, slow adhesion formation, cytotoxicity concerns, and lack of antibacterial properties. Herein, an injectable hydrogel (denoted as ES gel) with rapid, robust adhesive sealing and inherent antibacterial activity based on epsilon-polylysine and a poly(ethylene glycol) derivative is developed. The engineered hydrogel exhibits rapid gelation behavior, high mechanical strength, strong adhesion to various tissues, and can sustain an ultrahigh burst pressure of 450 mmHg. It also presents excellent biocompatibility, biodegradability, antibacterial properties, and on-demand removability. Significantly improved hemostatic efficacy of ES gel compared to fibrin glue is demonstrated using various injury models in rats and rabbits. Remarkably, the adhesive hydrogel can effectively halt lethal non-compressible hemorrhages in visceral organs (liver, spleen, and heart) and femoral artery injury models in fully anticoagulated pigs. Furthermore, the hydrogel outperforms commercial products in sutureless wound closure and repair in the rat liver defect, skin incision, and infected full-thickness skin wound models. Overall, this study highlights the promising clinical applications of ES gel for managing uncontrolled hemorrhage, sutureless wound closure, and infected wound repair.","An injectable hydrogel with excellent biocompatibility, biodegradability, inherent antibacterial activity, and on-demand removability is developed using epsilon-polylysine and tetra-armed poly(ethylene glycol) succinimidyl succinate. The optimized hydrogel gelatinizes rapidly, sustains ultrahigh burst pressure, and effectively stops lethal hemorrhage in anticoagulated large animals. Furthermore, it facilitates sutureless repair of liver defects, skin incisions, and infected full-thickness skin wounds in rat models. image"]

hemostatic hydrogels inherent antibacterial activity injectable adhesives tissue repair wound healing

SCI ; EI

英语

第一 ; 通讯

Ministry of Science and Technology of China[2020YFA0908900] ; Shenzhen Science and Technology Innovation Commission["KQTD20200820113012029","JCYJ20190814114605162","JCYJ20220818100601003"] ; Guangdong Basic and Applied Basic Research Foundation["2022A1515110321","2024A1515011621"] ; Guangdong Provincial Key Laboratory of Advanced Biomaterials[2022B1212010003] ; null[21935011] ; null[21725403]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:001251542900001

WILEY-V C H VERLAG GMBH

MATERIALS SCIENCE

Web of Science

1.Southern Univ Sci & Technol, Dept Biomed Engn, Guangdong Prov Key Lab Adv Biomat, 1088 Xueyuan Ave, Shenzhen 518055, Guangdong, Peoples R China
2.Southern Med Univ, Shenzhen Hosp, Dept Maxillofacial Surg, 1333 Xinhu Rd, Shenzhen 518101, Guangdong, Peoples R China

Yang, Yu,He, Gang,Pan, Zheng,et al. An Injectable Hydrogel with Ultrahigh Burst Pressure and Innate Antibacterial Activity for Emergency Hemostasis and Wound Repair[J]. ADVANCED MATERIALS,2024.

Yang, Yu.,He, Gang.,Pan, Zheng.,Zhang, Kaiwen.,Xian, Yiwen.,...&Wu, Decheng.(2024).An Injectable Hydrogel with Ultrahigh Burst Pressure and Innate Antibacterial Activity for Emergency Hemostasis and Wound Repair.ADVANCED MATERIALS.

Yang, Yu,et al."An Injectable Hydrogel with Ultrahigh Burst Pressure and Innate Antibacterial Activity for Emergency Hemostasis and Wound Repair".ADVANCED MATERIALS (2024).