Glucose metabolic reprogramming-related parameters for the prediction of 28-day neurological prognosis and all-cause mortality in patients after cardiac arrest: a prospective single-center observational study

Abudurexiti, Subi1; Xu, Shihai2,3; Sun, Zhangping4; Jiang, Yi5; Gong, Ping2,3

2024-05-01

10.5847/wjem.j.1920-8642.2024.047

WORLD JOURNAL OF EMERGENCY MEDICINE   影响因子和分区

1920-8642

BACKGROUND: We aimed to observe the dynamic changes in glucose metabolic reprogrammingrelated parameters and their ability to predict neurological prognosis and all -cause mortality in cardiac arrest patients after the restoration of spontaneous circulation (ROSC). METHODS: Adult cardiac arrest patients after ROSC who were admitted to the emergency or cardiac intensive care unit of the First Affi liated Hospital of Dalian Medical University from August 1, 2017, to May 30, 2021, were enrolled. According to 28 -day survival, the patients were divided into a non -survival group (n=82) and a survival group (n=38). Healthy adult volunteers (n=40) of similar ages and sexes were selected as controls. The serum levels of glucose metabolic reprogrammingrelated parameters (lactate dehydrogenase [LDH], lactate and pyruvate), neuron -specific enolase (NSE) and interleukin 6 (IL -6) were measured on days 1, 3, and 7 after ROSC. The Acute Physiology and Chronic Health Evaluation II (APACHE II) score and Sequential Organ Failure Assessment (SOFA) score were calculated. The Cerebral Performance Category (CPC) score was recorded on day 28 after ROSC. RESULTS: Following ROSC, the serum LDH (607.0 U/L vs. 286.5 U/L), lactate (5.0 mmol/L vs. 2.0 mmol/L), pyruvate (178.0 mu mol/L vs. 70.9 mu mol/L), and lactate/pyruvate ratio (34.1 vs. 22.1) signifi cantly increased and were higher in the non -survivors than in the survivors on admission (all P<0.05). Moreover, the serum LDH, pyruvate, IL -6, APACHE II score, and SOFA score on days 1, 3 and 7 after ROSC were signifi cantly associated with 28 -day poor neurological prognosis and 28day all -cause mortality (all P<0.05). The serum LDH concentration on day 1 after ROSC had an area under the receiver operating characteristic curve (AUC) of 0.904 [95% confidence interval [95% CI]: 0.851-0.957]) with 96.8% specificity for predicting 28 -day neurological prognosis and an AUC of 0.950 (95% CI: 0.911-0.989) with 94.7% specifi city for predicting 28 -day all -cause mortality, which was the highest among the glucose metabolic reprogramming -related parameters tested. CONCLUSION: Serum parameters related to glucose metabolic reprogramming were significantly increased after ROSC. Increased serum LDH and pyruvate levels, and lactate/pyruvate ratio may be associated with 28 -day poor neurological prognosis and all -cause mortality after ROSC, and the predictive effi cacy of LDH during the fi rst week was superior to others.

Glucose metabolic reprogramming Lactate dehydrogenase Cardiac arrest Prognosis

SCI

英语

通讯

Shenzhen Science and Technology Program[JCYJ20230807112007014] ; Shenzhen Key Medical Discipline Construction Fund[SZXK046]

Emergency Medicine

Emergency Medicine

WOS:001251300500006

ZHEJIANG UNIV PRESS

Web of Science

1.Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Emergency Med, Shanghai 200025, Peoples R China
2.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Emergency Med, Shenzhen 518020, Peoples R China
3.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Peoples R China
4.Dalian Med Univ, Affiliated Hosp 1, Dept Emergency Med, Dalian 116011, Peoples R China
5.Tianjin Med Univ, Gen Hosp, Dept Emergency Med, Tianjin 300052, Peoples R China

Abudurexiti, Subi,Xu, Shihai,Sun, Zhangping,et al. Glucose metabolic reprogramming-related parameters for the prediction of 28-day neurological prognosis and all-cause mortality in patients after cardiac arrest: a prospective single-center observational study[J]. WORLD JOURNAL OF EMERGENCY MEDICINE,2024,15(3).

Abudurexiti, Subi,Xu, Shihai,Sun, Zhangping,Jiang, Yi,&Gong, Ping.(2024).Glucose metabolic reprogramming-related parameters for the prediction of 28-day neurological prognosis and all-cause mortality in patients after cardiac arrest: a prospective single-center observational study.WORLD JOURNAL OF EMERGENCY MEDICINE,15(3).

Abudurexiti, Subi,et al."Glucose metabolic reprogramming-related parameters for the prediction of 28-day neurological prognosis and all-cause mortality in patients after cardiac arrest: a prospective single-center observational study".WORLD JOURNAL OF EMERGENCY MEDICINE 15.3(2024).