南方科技大学知识苑(SUSTech KC): Circular RNA vaccines against monkeypox virus provide potent protection against vaccinia virus infection in mice

题名	Circular RNA vaccines against monkeypox virus provide potent protection against vaccinia virus infection in mice
作者	Zhou, Jinge 1,2; Ye, Tianxi 1,2,9; Yang, Yun 3,9; Li, Entao 4,5,9; Zhang, Kaiyue 1; Wang, Yuping 1; Chen, Shaohong 1,2; Hu, Jiang 3; Zhang, Kai 3; Liu, Fang 3; Gong, Rui 2,6,7,9; Chuai, Xia 1,10; Wang, Zefeng3,8 ; Chiu, Sandra 4,5
通讯作者	Gong, Rui; Chuai, Xia; Wang, Zefeng; Chiu, Sandra
发表日期	2024-06-05
DOI	10.1016/j.ymthe.2024.04.028
发表期刊	MOLECULAR THERAPY 影响因子和分区
ISSN	1525-0016
EISSN	1525-0024
卷号	32 期号:6
摘要	Since the outbreak of monkeypox (mpox) in 2022, widespread concern has been placed on imposing an urgent demand for speci fi c vaccines that offer safer and more effective protection. Using an ef fi cient and scalable circular RNA (circRNA) platform, we constructed four circRNA vaccines that could induce robust neutralizing antibodies as well as T cell responses by expressing different surface proteins of mpox virus (MPXV), resulting in potent protection against vaccinia virus (VACV) in mice. Strikingly, the combination of the four circular RNA vaccines demonstrated the best protection against VACV challenge among all the tested vaccines. Our study provides a favorable approach for developing MPXV-speci fi c vaccines by using a circular mRNA platform and opens up novel avenues for future vaccine research.
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	通讯
资助项目	National Key Research and Development Program of China[2022YFC2304102] ; USTC Research Funds of the Double First-Class Initiative[YD9100002040]
WOS研究方向	Biotechnology & Applied Microbiology ; Genetics & Heredity ; Research & Experimental Medicine
WOS类目	Biotechnology & Applied Microbiology ; Genetics & Heredity ; Medicine, Research & Experimental
WOS记录号	WOS:001251669100001
出版者	CELL PRESS
ESI学科分类	CLINICAL MEDICINE
来源库	Web of Science
引用统计	被引频次[WOS]：1
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/787555
专题	生命科学学院
作者单位	1.Chinese Acad Sci, Wuhan Inst Virol, Ctr Biosafety Mega Sci, State Key Lab Virol, Wuhan 430207, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Shanghai CirCode Biomed Co Ltd, Res & Dev Dept, Shanghai 200131, Peoples R China 4.Univ Sci & Technol China, Div Life Sci & Med, Hefei 230027, Anhui, Peoples R China 5.Key Lab Anhui Prov Emerging & Reemerging Infect Di, Hefei 230027, Anhui, Peoples R China 6.Chinese Acad Sci, Wuhan Inst Virol, Ctr Biosafety Mega Sci, CAS Key Lab Special Pathogens & Biosafety, Wuhan 430207, Hubei, Peoples R China 7.Hubei Jiangxia Lab, Wuhan 430200, Hubei, Peoples R China 8.Southern Univ Sci & Technol, Sch Life Sci, Shenzhen 518055, Peoples R China 9.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 10.Chinese Acad Sci, Wuhan Inst Virol, Ctr Biosafety Mega Sci, State Key Lab Virol, Wuhan 430207, Peoples R China
通讯作者单位	生命科学学院
推荐引用方式 GB/T 7714	Zhou, Jinge,Ye, Tianxi,Yang, Yun,et al. Circular RNA vaccines against monkeypox virus provide potent protection against vaccinia virus infection in mice[J]. MOLECULAR THERAPY,2024,32(6).
APA	Zhou, Jinge.,Ye, Tianxi.,Yang, Yun.,Li, Entao.,Zhang, Kaiyue.,...&Chiu, Sandra.(2024).Circular RNA vaccines against monkeypox virus provide potent protection against vaccinia virus infection in mice.MOLECULAR THERAPY,32(6).
MLA	Zhou, Jinge,et al."Circular RNA vaccines against monkeypox virus provide potent protection against vaccinia virus infection in mice".MOLECULAR THERAPY 32.6(2024).