Intracranial tuberculomas diagnosed with Xpert MTB/RIF Ultra assay of formalin-fixed paraffin-embedded brain tissues and treated with an optimized antituberculosis regimen: A case report

Jin, Wang1,2; Qifu, Chen3; Hong, Yu4; Hua, Huang5; Xuelin, Li6; Xiaomin, Wang2; Shuihua, Lu1,2; Mutong, Fang1,2

2024-06-15

10.1016/j.heliyon.2024.e32462

HELIYON   影响因子和分区

2405-8440

Diagnosis of intracranial tuberculoma remains a challenge due to its rarity, non-specific clinical presentation, and radiological findings. Herein, we describe a case of intracranial tuberculomas in a male diabetic patient who presented headache and vomiting on admission. Neuroimaging findings indicated multiple ring contrast-enhanced lesions with extensive perilesional edema. However, a cerebrospinal fluid (CSF) examination was normal. When a biopsy of brain lesions was performed, pathological characteristics of tuberculosis were absent and acid-fast staining was negative. A tuberculosis diagnosis was subsequently obtained from an Xpert MTB/RIF Ultra assay of formalin-fixed paraffin-embedded brain tissue. The patient was treated with an optimized antituberculosis regimen which included high-dose intravenous administration of rifampicin and isoniazid, and oral administration of linezolid. The patient recovered well and exhibited marked clinical improvement. This case report demonstrates that when CSF analysis does not indicate the presence of intracranial tuberculomas, analysis of formalin-fixed paraffin-embedded brain tissue specimens with the Xpert MTB/RIF Ultra assay may be able to confirm a diagnosis. Furthermore, a high dose of rifampicin and isoniazid plus linezolid may improve patient outcome.

Intracranial tuberculoma Brain biopsy Xpert MTB/RIF Ultra assay Case report

SCI

英语

第一 ; 通讯

Project of Shenzhen Third People ' s Hospital[G2022058] ; Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties[SZGSP010]

Science & Technology - Other Topics

Multidisciplinary Sciences

WOS:001251477300001

CELL PRESS

Web of Science

1.Southern Univ Sci & Technol, Peoples Hosp Shenzhen 3, Div Pulm Dis Dept, Shenzhen, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Natl Clin Res Ctr Infect Dis, Shenzhen, Guangdong, Peoples R China
3.Southern Univ Sci & Technol, Peoples Hosp Shenzhen 3, Dept Neurosurg, Shenzhen, Guangdong, Peoples R China
4.Southern Univ Sci & Technol, Peoples Hosp Shenzhen 3, Dept Pathol, Shenzhen, Guangdong, Peoples R China
5.Southern Univ Sci & Technol, Peoples Hosp Shenzhen 3, Dept Radiol, Shenzhen, Guangdong, Peoples R China
6.Southern Univ Sci & Technol, Peoples Hosp Shenzhen 3, Dept Clin Lab, Shenzhen, Guangdong, Peoples R China

Jin, Wang,Qifu, Chen,Hong, Yu,et al. Intracranial tuberculomas diagnosed with Xpert MTB/RIF Ultra assay of formalin-fixed paraffin-embedded brain tissues and treated with an optimized antituberculosis regimen: A case report[J]. HELIYON,2024,10(11).

Jin, Wang.,Qifu, Chen.,Hong, Yu.,Hua, Huang.,Xuelin, Li.,...&Mutong, Fang.(2024).Intracranial tuberculomas diagnosed with Xpert MTB/RIF Ultra assay of formalin-fixed paraffin-embedded brain tissues and treated with an optimized antituberculosis regimen: A case report.HELIYON,10(11).

Jin, Wang,et al."Intracranial tuberculomas diagnosed with Xpert MTB/RIF Ultra assay of formalin-fixed paraffin-embedded brain tissues and treated with an optimized antituberculosis regimen: A case report".HELIYON 10.11(2024).