Double-Layered Metal-Organic-Frameworks-Based Microswimmers for Adaptive Dual-Drug Anti-Cancer Therapy Using Artemisinin-Based Compounds

Zhong, Yukun1; Li, Haining2; Jiang, Teng1; Mu, Xueliang3; Seki, Munetoshi2; Cheang, U. Kei1

2024-06-01

10.1002/aisy.202400244

ADVANCED INTELLIGENT SYSTEMS   影响因子和分区

2640-4567

["Magnetic microrobots have the potential for anti-cancer drug delivery; however, using dual-drug to counter drug resistance, a critical issue in cancer research, has only been briefly investigated. This study introduces the double-layered metal-organic-frameworks (MOFs)-based microswimmers for sustained dual-drug delivery. These microswimmers are made up of ZIF-8 and MIL-100, biocompatible MOFs, that can selectively adsorb two types of drugs. The MOFs increase the surface area of the microswimmers by approximate to 2.42 times, which greatly enhances drug adsorption, and improves hydrophilicity, which reduces adhesion for surface locomotion. Their biocompatibility and dual-drug adsorption are verified through cell viability and drug-loading tests. The microswimmers have remarkable versatility in loading different drug combinations (DHA + 5-FU, CPT-11, or DOX), indicating the potential for adaptive therapy. They can inhibit cancer cells for up to 72 h through the sustained release of dual drugs. In contrast, drug treatments without microswimmers only inhibit cell proliferation for 24 h, leading to a significant rebound. This study provides a method to mass fabricate fully biocompatible microrobots with dual drug loading versatility and high drug adsorption capacity; thus, suggests a powerful platform for sustained adaptive dual-drug therapy.","This study introduces a novel approach to the design of microswimmers based on double-layered metal-organic-framework (MOFs) for sustained dual-drug delivery and reduced hydrophobicity for locomotion. These biocompatible modified microswimmers enhance drug adsorption and allow versatile loading of different drug combinations, effectively inhibiting cancer cells for up to 72 h. This innovation represents an approach to adaptive dual-drug delivery therapy.image (c) 2024 WILEY-VCH GmbH"]

dual-drug magnetic control metal-organic-frameworks microrobot microswimmer

SCI ; EI

英语

第一 ; 通讯

Department of Education of Guangdong[2021ZDZX2037] ; Guangdong Basic and Applied Basic Research Foundation[2023A1515012229] ; Science and Technology Innovation Committee Foundation of Shenzhen[RCYX20210609103644015] ; null[52375569]

Automation & Control Systems ; Computer Science ; Robotics

Automation & Control Systems ; Computer Science, Artificial Intelligence ; Robotics

WOS:001250565800001

WILEY

Web of Science

1.Southern Univ Sci & Technol, Dept Mech & Energy Engn, Shenzhen 518055, Peoples R China
2.Univ Tokyo, Grad Sch Engn, Dept Elect Engn & Informat Syst, Tokyo 1138656, Japan
3.Univ Calgary, Dept Mech & Mfg Engn, Calgary, AB T2N 1N4, Canada

Zhong, Yukun,Li, Haining,Jiang, Teng,et al. Double-Layered Metal-Organic-Frameworks-Based Microswimmers for Adaptive Dual-Drug Anti-Cancer Therapy Using Artemisinin-Based Compounds[J]. ADVANCED INTELLIGENT SYSTEMS,2024.

Zhong, Yukun,Li, Haining,Jiang, Teng,Mu, Xueliang,Seki, Munetoshi,&Cheang, U. Kei.(2024).Double-Layered Metal-Organic-Frameworks-Based Microswimmers for Adaptive Dual-Drug Anti-Cancer Therapy Using Artemisinin-Based Compounds.ADVANCED INTELLIGENT SYSTEMS.

Zhong, Yukun,et al."Double-Layered Metal-Organic-Frameworks-Based Microswimmers for Adaptive Dual-Drug Anti-Cancer Therapy Using Artemisinin-Based Compounds".ADVANCED INTELLIGENT SYSTEMS (2024).