Deep Red Light Driven Hydrogen Evolution by Heterojunction Polymer Dots for Diabetic Wound Healing

Mi, Feixue1; Liu, Zhao2,3; Wang, Xinyu1; Wang, Yingjie4; Yang, Junfeng5; Wang, Zhe5; Yin, Shengyan5; Fang, Xiaofeng1; Shu, Peng2,3; Zhang, Xuanjun6; Wu, Changfeng1

2024-07-15

10.1002/anie.202402133

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   影响因子和分区

1433-7851

1521-3773

We describe small heterojunction polymer dots (Pdots) with deep-red light catalyzed H-2 generation for diabetic skin wound healing. The Pdots with donor/acceptor heterojunctions showed remarkably enhanced photocatalytic activity as compared to the donor or acceptor nanoparticles alone. We encapsulate the Pdots and ascorbic acid into liposomes to form Lipo-Pdots nanoreactors, which selectively scavenge center dot OH radicals in live cells and tissues under 650 nm light illumination. The antioxidant capacity of the heterojunction Pdots is similar to 10 times higher than that of the single-component Pdots described previously. Under a total light dose of 360 J/cm(2), the Lipo-Pdots nanoreactors effectively scavenged center dot OH radicals and suppressed the expression of pro-inflammatory cytokines in skin tissues, thereby accelerating the healing of skin wounds in diabetic mice. This study provides a feasible solution for safe and effective treatment of diabetic foot ulcers.

photocatalysis hydrogen evolution heterojunction polymer dots diabetic wound healing

SCI ; EI

英语

第一 ; 通讯

National Key R&D Program of China[2020YFA0909000] ; Shenzhen Science and Technology Program["KQTD20170810111314625","JCYJ20210324115807021","SGDX20211123114002003"] ; Shenzhen Bay Laboratory[SZBL2021080601002] ; Guangdong Provincial Key Laboratory of Advanced Biomaterials[2022B1212010003] ; null[62235007] ; null[22204070]

Chemistry

Chemistry, Multidisciplinary

WOS:001247392000001

WILEY-V C H VERLAG GMBH

20242416260662

Heterojunctions ; Histology ; Hydrogen ; Mammals ; Photocatalytic activity ; Tissue

Biological Materials and Tissue Engineering:461.2 ; Biology:461.9 ; Semiconductor Devices and Integrated Circuits:714.2 ; Physical Chemistry:801.4 ; Chemical Products Generally:804

CHEMISTRY

Web of Science

1.Southern Univ Sci & Technol, Dept Biomed Engn, Opt Mol & Skin Imaging Joint Lab, Shenzhen 518055, Guangdong, Peoples R China
2.Shenzhen Hujia Technol Co Ltd, HBN Res Inst, Shenzhen 518000, Guangdong, Peoples R China
3.Shenzhen Hujia Technol Co Ltd, Biol Lab, Shenzhen 518000, Guangdong, Peoples R China
4.Shenzhen Bay Lab, Shenzhen 518132, Guangdong, Peoples R China
5.Jilin Univ, Coll Elect Sci & Engn, State Key Lab Integrated Optoelect, Changchun 130012, Jilin, Peoples R China
6.Univ Macau, Fac Hlth Sci, Macau 999078, Peoples R China

Mi, Feixue,Liu, Zhao,Wang, Xinyu,et al. Deep Red Light Driven Hydrogen Evolution by Heterojunction Polymer Dots for Diabetic Wound Healing[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2024,63(29).

Mi, Feixue.,Liu, Zhao.,Wang, Xinyu.,Wang, Yingjie.,Yang, Junfeng.,...&Wu, Changfeng.(2024).Deep Red Light Driven Hydrogen Evolution by Heterojunction Polymer Dots for Diabetic Wound Healing.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,63(29).

Mi, Feixue,et al."Deep Red Light Driven Hydrogen Evolution by Heterojunction Polymer Dots for Diabetic Wound Healing".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 63.29(2024).