Obstructive Sleep Apnea as a Key Contributor to Mental Stress-Induced Myocardial Ischemia in Female Angina Patients with No Obstructive Coronary Artery Disease

Liu, Fengyao1,2; Wang, Haochen2,3; Bai, Bingqing2,4; Yin, Han5; Liu, Yuting2; Wang, Yu2; Liu, Quanjun2; Wang, Shuxia6; Ma, Huan3,7; Geng, Qingshan1,2,5,8

2024

10.2147/NSS.S445219

NATURE AND SCIENCE OF SLEEP   影响因子和分区

1179-1608

Purpose: Mental stress induced myocardial ischemia (MSIMI) is regarded as the primary cause of the angina with no obstructive coronary artery disease (ANOCA). Obstructive sleep apnea (OSA) is autonomously linked to obstructive coronary heart disease, hypertension, and sudden cardiac death. Similar to the impact of psychological stress on the cardiovascular system, individuals with OSA experience periodic nocturnal hypoxia, resulting in the activation of systemic inflammation, oxidative stress, endothelial dysfunction, and sympathetic hyperactivity. The contribution of OSA to MSIMI in ANOCA patients is unclear. To explore the prevalence of OSA in ANOCA patients and the correlation between OSA and MSIMI, a prospective cohort of female ANOCA patients was recruited. Patients and Methods: We recruited female patients aged 18 to 75 years old with ANOCA and evaluated MSIMI using positron emission tomography-computed tomography. Subsequently, Level III portable monitors was performed to compare the relationship Results: There is higher REI (7.8 vs 2.6, P=0.019), ODI (4.7 vs 9.2, P=0.028) and percentage of OSA (67.74% vs 33.33%, P=0.004) in MSIMI patients. The patients diagnosed with OSA demonstrated higher myocardial perfusion imaging scores (SSS: 1.5 vs 3, P = 0.005, SDS: 1 vs 3, P = 0.007). Adjusted covariates, the risk of developing MSIMI remained 3.6 times higher in OSA patients (beta=1.226, OR = 3.408 (1.200-9.681), P = 0.021). Conclusion: Patients with MSIMI exhibit a greater prevalence of OSA. Furthermore, the myocardial blood flow perfusion in patients with OSA is reduced during mental stress.

obstructive sleep apnea mental stress induced myocardial ischemia angina with no obstructive coronary artery disease myocardial perfusion imaging

SCI

英语

通讯

High-level Hospital Construction Project of Guangdong Provincial People's Hospital["DFJH201811","DFJH201922","DFJH2020029"] ; Guangdong Province Medical Science and Technology Research Fund Project[B202314] ; Natural Science Foundation of Guangdong Province["2021A1515011118","2021A1515011781"]

Neurosciences & Neurology

Clinical Neurology ; Neurosciences

WOS:001248759000001

DOVE MEDICAL PRESS LTD

Web of Science

1.South China Univ Technol, Sch Med, Guangzhou, Peoples R China
2.Southern Med Univ, Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Guangzhou, Peoples R China
3.Southern Med Univ, Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, Guangdong Acad Med Sci, Guangzhou, Peoples R China
4.South China Univ Technol, Sch Biomed Sci & Engn, Guangzhou, Peoples R China
5.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2,Affiliated Hosp 1, Shenzhen, Peoples R China
6.Southern Med Univ, Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Dept Nucl Med, Guangzhou, Peoples R China
7.Southern Med Univ, Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Dept Cardiol,Guangdong Cardiovasc Inst, 106 Zhongshan Er Rd, Guangzhou, Peoples R China
8.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Dept Cardiol,Clin Med Coll 2, 1080 Cuizhu Rd, Shenzhen, Guangdong, Peoples R China

Liu, Fengyao,Wang, Haochen,Bai, Bingqing,et al. Obstructive Sleep Apnea as a Key Contributor to Mental Stress-Induced Myocardial Ischemia in Female Angina Patients with No Obstructive Coronary Artery Disease[J]. NATURE AND SCIENCE OF SLEEP,2024,16.

Liu, Fengyao.,Wang, Haochen.,Bai, Bingqing.,Yin, Han.,Liu, Yuting.,...&Geng, Qingshan.(2024).Obstructive Sleep Apnea as a Key Contributor to Mental Stress-Induced Myocardial Ischemia in Female Angina Patients with No Obstructive Coronary Artery Disease.NATURE AND SCIENCE OF SLEEP,16.

Liu, Fengyao,et al."Obstructive Sleep Apnea as a Key Contributor to Mental Stress-Induced Myocardial Ischemia in Female Angina Patients with No Obstructive Coronary Artery Disease".NATURE AND SCIENCE OF SLEEP 16(2024).