Unlocking Glioblastoma Vulnerabilities with CRISPR-Based Genetic Screening

Fang, Yitong1,2; Li, Xing1,2; Tian, Ruilin1,2

2024-06-01

10.3390/ijms25115702

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   影响因子和分区

1661-6596

1422-0067

Glioblastoma (GBM) is the most common malignant brain tumor in adults. Despite advancements in treatment, the prognosis for patients with GBM remains poor due to its aggressive nature and resistance to therapy. CRISPR-based genetic screening has emerged as a powerful tool for identifying genes crucial for tumor progression and treatment resistance, offering promising targets for tumor therapy. In this review, we provide an overview of the recent advancements in CRISPR-based genetic screening approaches and their applications in GBM. We highlight how these approaches have been used to uncover the genetic determinants of GBM progression and responsiveness to various therapies. Furthermore, we discuss the ongoing challenges and future directions of CRISPR-based screening methods in advancing GBM research.

glioblastoma CRISPR-based genetic screening therapy resistance genetic determinants therapeutic targets

SCI

英语

第一 ; 通讯

Biochemistry & Molecular Biology ; Chemistry

Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary

WOS:001246548400001

MDPI

CHEMISTRY

Web of Science

1.Southern Univ Sci & Technol, Sch Med, Dept Med Neurosci, Shenzhen 518055, Peoples R China
2.Southern Univ Sci & Technol, Key Univ Lab Metab & Hlth Guangdong, Shenzhen 518055, Peoples R China

Fang, Yitong,Li, Xing,Tian, Ruilin. Unlocking Glioblastoma Vulnerabilities with CRISPR-Based Genetic Screening[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2024,25(11).

Fang, Yitong,Li, Xing,&Tian, Ruilin.(2024).Unlocking Glioblastoma Vulnerabilities with CRISPR-Based Genetic Screening.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,25(11).

Fang, Yitong,et al."Unlocking Glioblastoma Vulnerabilities with CRISPR-Based Genetic Screening".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 25.11(2024).