南方科技大学知识苑(SUSTech KC): AURKB targets DHX9 to promote hepatocellular carcinoma progression via PI3K/AKT/mTOR pathway

题名	AURKB targets DHX9 to promote hepatocellular carcinoma progression via PI3K/AKT/mTOR pathway
作者	Zhu, Guoqing 1,2; Luo, Laihui 2; He, Yongzhu 2,3,4; Xiao, Yongqiang 2; Cai, Ziwei 2; Tong, Weilai 5; Deng, Wei 2; Xie, Jin 2; Zhong, Yanxin 5; Hu, Zhigao 2; Shan, Renfeng 2
通讯作者	Hu, Zhigao; Shan, Renfeng
发表日期	2024-06-01
DOI	10.1002/mc.23775
发表期刊	MOLECULAR CARCINOGENESIS 影响因子和分区
ISSN	0899-1987
EISSN	1098-2744
摘要	Aurora kinase B (AURKB) is known to play a carcinogenic role in a variety of cancers, but its underlying mechanism in liver cancer is unknown. This study aimed to investigate the role of AURKB in hepatocellular carcinoma (HCC) and its underlying molecular mechanism. Bioinformatics analysis revealed that AURKB was significantly overexpressed in HCC tissues and cell lines, and its high expression was associated with a poorer prognosis in HCC patients. Furthermore, downregulation of AURKB inhibited HCC cell proliferation, migration, and invasion, induced apoptosis, and caused cell cycle arrest. Moreover, AURKB downregulation also inhibited lung metastasis of HCC. AURKB interacted with DExH-Box helicase 9 (DHX9) and targeted its expression in HCC cells. Rescue experiments further demonstrated that AURKB targeting DHX9 promoted HCC progression through the PI3K/AKT/mTOR pathway. Our results suggest that AURKB is significantly highly expressed in HCC and correlates with patient prognosis. Targeting DHX9 with AURKB promotes HCC progression via the PI3K/AKT/mTOR pathway.
关键词	AURKB DHX9 HCC PI3K/AKT/mTOR pathway protein interaction
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	其他
资助项目	Jiangxi Provincial Department of Science and Technology[20202BBGL73092]
WOS研究方向	Biochemistry & Molecular Biology ; Oncology
WOS类目	Biochemistry & Molecular Biology ; Oncology
WOS记录号	WOS:001246139400001
出版者	WILEY
ESI学科分类	CLINICAL MEDICINE
来源库	Web of Science
引用统计
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/787948
专题	南方科技大学第一附属医院
作者单位	1.Nanchang Univ, Hosp Nanchang 1, Affiliated Hosp 3, Dept Gen Surg, Nanchang, Jiangxi, Peoples R China 2.Nanchang Univ, Affiliated Hosp 1, Dept Gen Surg, 17 Yong Wai Zheng St, Nanchang 330006, Jiangxi, Peoples R China 3.Jinan Univ, Clin Med Coll 2, Div Hepatobiliary & Pancreas Surg, Dept Gen Surg,Shenzhen Peoples Hosp, Shenzhen, Guangdong, Peoples R China 4.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Guangdong, Peoples R China 5.Nanchang Univ, Affiliated Hosp 1, Dept Orthoped, Nanchang, Jiangxi, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Guoqing,Luo, Laihui,He, Yongzhu,et al. AURKB targets DHX9 to promote hepatocellular carcinoma progression via PI3K/AKT/mTOR pathway[J]. MOLECULAR CARCINOGENESIS,2024.
APA	Zhu, Guoqing.,Luo, Laihui.,He, Yongzhu.,Xiao, Yongqiang.,Cai, Ziwei.,...&Shan, Renfeng.(2024).AURKB targets DHX9 to promote hepatocellular carcinoma progression via PI3K/AKT/mTOR pathway.MOLECULAR CARCINOGENESIS.
MLA	Zhu, Guoqing,et al."AURKB targets DHX9 to promote hepatocellular carcinoma progression via PI3K/AKT/mTOR pathway".MOLECULAR CARCINOGENESIS (2024).