题名 | AIDA-1/ANKS1B Binds to the SynGAP Family RasGAPs with High Affinity and Specificity |
作者 | |
通讯作者 | Wang, Xueqian; Zhang, Mingjie |
共同第一作者 | Wang, Xueqian; Wang, Yu |
发表日期 | 2024-06-15
|
DOI | |
发表期刊 | |
ISSN | 0022-2836
|
EISSN | 1089-8638
|
卷号 | 436期号:12 |
摘要 | AIDA-1, encoded by ANKS1B, is an abundant postsynaptic scaffold protein essential for brain development. Mutations of ANKS1B are closely associated with various psychiatric disorders. However, very little is known regarding the molecular mechanisms underlying AIDA-1's involvements under physiological and pathophysiological conditions. Here, we discovered an interaction between AIDA-1 and the SynGAP family Ras-GTPase activating protein (GAP) via affinity purification using AIDA-1d as the bait. Biochemical studies showed that the PTB domain of AIDA-1 binds to an extended NPx[F/Y]-motif of the SynGAP family proteins with high affinities. The high-resolution crystal structure of AIDA-1 PTB domain in complex with the SynGAP NPxF-motif revealed the molecular mechanism governing the specific interaction between AIDA-1 and SynGAP. Our study not only explains why patients with ANKS1B or SYNGAP1 mutations share overlapping clinical phenotypes, but also allows identification of new AIDA-1 binding targets such (c) 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies. |
相关链接 | [来源记录] |
收录类别 | |
语种 | 英语
|
学校署名 | 共同第一
; 通讯
|
资助项目 | Ministry of Science and Technology of China[2019YFA0508402]
; Shenzhen Bay Laboratory[S201101002]
; Shenzhen Talent Program[KQTD20210811090115021]
; Shenzhen Science and Technology Basic Research Program[JCYJ20220818100215033]
; Shenzhen Key Laboratory[ZDSYS20220402111000001]
; Guangdong Innovative and Entrepreneurial Research Team Program[2021ZT09Y104]
|
WOS研究方向 | Biochemistry & Molecular Biology
|
WOS类目 | Biochemistry & Molecular Biology
|
WOS记录号 | WOS:001247397700001
|
出版者 | |
ESI学科分类 | MOLECULAR BIOLOGY & GENETICS
|
来源库 | Web of Science
|
引用统计 | |
成果类型 | 期刊论文 |
条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/787985 |
专题 | 生命科学学院 |
作者单位 | 1.Hong Kong Univ Sci & Technol, Shenzhen Peking Univ, Biomed Res Inst, Med Ctr, Shenzhen 518036, Peoples R China 2.Hong Kong Univ Sci & Technol, Div Life Sci, Clear Water Bay, Hong Kong, Peoples R China 3.Xiamen Univ, Sch Publ Hlth, State Key Lab Vaccines Infect Dis, Xiamen, Fujian, Peoples R China 4.Shenzhen Bay Lab, Greater Bay Biomed Innocenter, Shenzhen 518036, Peoples R China 5.Southern Univ Sci & Technol, Sch Life Sci, Shenzhen 518055, Peoples R China |
通讯作者单位 | 生命科学学院 |
推荐引用方式 GB/T 7714 |
Wang, Xueqian,Wang, Yu,Cai, Qixu,et al. AIDA-1/ANKS1B Binds to the SynGAP Family RasGAPs with High Affinity and Specificity[J]. JOURNAL OF MOLECULAR BIOLOGY,2024,436(12).
|
APA |
Wang, Xueqian,Wang, Yu,Cai, Qixu,&Zhang, Mingjie.(2024).AIDA-1/ANKS1B Binds to the SynGAP Family RasGAPs with High Affinity and Specificity.JOURNAL OF MOLECULAR BIOLOGY,436(12).
|
MLA |
Wang, Xueqian,et al."AIDA-1/ANKS1B Binds to the SynGAP Family RasGAPs with High Affinity and Specificity".JOURNAL OF MOLECULAR BIOLOGY 436.12(2024).
|
条目包含的文件 | 条目无相关文件。 |
|
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论