Unlocking the NIR-II AIEgen for High Brightness through Intramolecular Electrostatic Locking

Wang, Xinyuan1,2,3; Yang, Xueqin2,3; Jiang, Guanyu4; Hu, Zhubin4; Liao, Tao7; Wang, Guoxin7; Zhang, Xun1; He, Xinyuan2,3; Zhang, Jianyu2,3; Zhang, Jianquan6; Cao, Wuke1; Zhang, Kaizhen1; Lam, Jacky W. Y.2,3; Sun, Jianwei2,3; Sun, Haitao4,5; Liang, Yongye1; Tang, Ben Zhong2,3,6

2024-07-15

10.1002/anie.202404142

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   影响因子和分区

1433-7851

1521-3773

["Fluorescent imaging and biosensing in the near-infrared-II (NIR-II) window holds great promise for non-invasive, radiation-free, and rapid-response clinical diagnosis. However, it's still challenging to develop bright NIR-II fluorophores. In this study, we report a new strategy to enhance the brightness of NIR-II aggregation-induced emission (AIE) fluorophores through intramolecular electrostatic locking. By introducing sulfur atoms into the side chains of the thiophene bridge in TSEH molecule, the molecular motion of the conjugated backbone can be locked through intramolecular interactions between the sulfur and nitrogen atoms. This leads to enhanced NIR-II fluorescent emission of TSEH in both solution and aggregation states. Notably, the encapsulated nanoparticles (NPs) of TSEH show enhanced brightness, which is 2.6-fold higher than TEH NPs with alkyl side chains. The in vivo experiments reveal the feasibility of TSEH NPs in vascular and tumor imaging with a high signal-to-background ratio and precise resection for tiny tumors. In addition, polystyrene nanospheres encapsulated with TSEH are utilized for antigen detection in lateral flow assays, showing a signal-to-noise ratio 1.9-fold higher than the TEH counterpart in detecting low-concentration antigens. This work highlights the potential for developing bright NIR-II fluorophores through intramolecular electrostatic locking and their potential applications in clinical diagnosis and biomedical research.","The alkylthio side chain on the thiophene bridge affords sulfur-nitrogen electrostatic lock, substantially improving the fluorescent brightness of the aggregation-induced emission luminogen (AIEgen) in the second near-infrared (NIR-II) window. The obtained NIR-II AIEgen shows high signal-to-noise ratio in NIR-II fluorescent imaging and high sensitivity in detecting low-concentration antigens. image"]

NIR-II fluorophores intramolecular electrostatic locking aggregation-induced emission imaging guided surgery lateral flow assay

SCI ; EI

英语

第一 ; 通讯

Research Grants Council of Hong Kong[C6014-20W] ; Innovation and Technology Commission["ITC-CNERC14SC01","ITCPD/17-9"] ; Shenzhen Key Laboratory of Functional Aggregate Materials[ccZDSYS20211021111400001] ; Science Technology Innovation Commission of Shenzhen Municipality[KQTD20210811090142053] ; Special Funds for the Cultivation of Guangdong College Students "Scientific and Technological Innovation"[pdjh2024c10903] ; National Natural Science Foundation of China[12274128] ; Shanghai Rising-Star Program[21QA1402600] ; null[JCYJ20200109141405950]

Chemistry

Chemistry, Multidisciplinary

WOS:001246121700001

WILEY-V C H VERLAG GMBH

20242416260691

Antigens ; Clinical research ; Diagnosis ; Electrostatics ; Fluorescence imaging ; Fluorophores ; Locks (fasteners) ; Signal to noise ratio ; Sulfur ; Tumors

Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Immunology:461.9.1 ; Electricity: Basic Concepts and Phenomena:701.1 ; Information Theory and Signal Processing:716.1 ; Light/Optics:741.1 ; Imaging Techniques:746 ; Physical Chemistry:801.4 ; Chemical Products Generally:804

CHEMISTRY

Web of Science

1.Southern Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen Key Lab Printed Organ Elect, Shenzhen 518055, Peoples R China
2.Hong Kong Univ Sci & Technol, Chinese Natl Engn Res Ctr Tissue Restorat & Recons, Dept Chem, Div Life Sci,Hong Kong Branch,Kowloon, Hong Kong 999077, Peoples R China
3.Hong Kong Univ Sci & Technol, State Key Lab Mol Neurosci, Kowloon, Hong Kong 999077, Peoples R China
4.East China Normal Univ, Sch Phys & Elect Sci, State Key Lab Precis Spect, Shanghai 200241, Peoples R China
5.Shanxi Univ, Collaborat Innovat Ctr Extreme Opt, Taiyuan 030006, Shanxi, Peoples R China
6.Chinese Univ Hong Kong CUHK Shenzhen, Shenzhen Inst Aggregate Sci & Technol, Sch Sci & Engn, Shenzhen 518172, Guangdong, Peoples R China
7.WWHS Biotech Inc, Shenzhen 518122, Peoples R China

Wang, Xinyuan,Yang, Xueqin,Jiang, Guanyu,et al. Unlocking the NIR-II AIEgen for High Brightness through Intramolecular Electrostatic Locking[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2024,63(29).

Wang, Xinyuan.,Yang, Xueqin.,Jiang, Guanyu.,Hu, Zhubin.,Liao, Tao.,...&Tang, Ben Zhong.(2024).Unlocking the NIR-II AIEgen for High Brightness through Intramolecular Electrostatic Locking.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,63(29).

Wang, Xinyuan,et al."Unlocking the NIR-II AIEgen for High Brightness through Intramolecular Electrostatic Locking".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 63.29(2024).