Secondhand Smoke Exposure and Risk of Dementia in Nonsmokers: A Population-Based Cohort Study

Wan, Zhongxiao1; Zhang, Xiaohui1; He, Huanying1; Zhang, Yebing1; Chen, Guo-Chong1; Qin, Li-Qiang1; Zhang, Na2; Li, Fu-Rong3,4

2024-06-01

10.1159/000535828

NEUROEPIDEMIOLOGY   影响因子和分区

0251-5350

1423-0208

Background: Large population-based prospective studies are necessary to provide clarification on the associations of panoramic secondhand smoking burden, including prenatal and postnatal secondhand smoke (SHS) exposure, with the risk of developing dementia. Methods: Our study comprised a sample of 353,756 dementia-free individuals from the UK Biobank who were nonsmokers had data on the exposure of maternal smoking as well as SHS exposure in daily life, which was quantified in terms of hours per week (h/week) and whether they lived with household smokers. Multivariable Cox regression models were utilized to analyze the independent and joint associations of maternal smoking and daily life SHS exposure with dementia risk. Results: During a median follow-up of 11.8 years, 4,113 participants developed dementia. Compared with those who lived in the environment without smokers, multivariable-adjusted hazard ratios (HRs) (95% CIs) were 1.11 (1.02, 1.20) and 1.31 (1.13, 1.52) for those who exposed to SHS for >0 but <= 4 h/week and >4 h/week, respectively, and was 1.25 (1.13, 1.39) for those who lived with smokers in the household. A positive history of maternal smoking was associated with a modestly higher risk of dementia (HR = 1.07; 95% CI: 1.01, 1.15). Furthermore, compared with participants with neither history of maternal smoking nor exposure to SHS, a particularly higher risk of dementia was observed among those with both exposures (HR = 1.48; 95% CI: 1.18, 1.86). Additionally, the HR (95% CI) was 1.32 (1.10, 1.59) when comparing participants with a history of maternal smoking who lived with smokers in their households with those who had neither exposures. Conclusions: Having a history of maternal smoking, longer exposure to SHS, and living with smokers in the household were each associated with an increased risk of developing dementia. Individuals who were simultaneously exposed to maternal smoking and SHS or lived with household smokers had a particularly higher dementia risk.

Secondhand smoke Maternal smoking Dementia Cohort study

SCI

英语

通讯

National Natural Science Foundation of China[82073535]

Public, Environmental & Occupational Health ; Neurosciences & Neurology

Public, Environmental & Occupational Health ; Clinical Neurology

WOS:001243731400002

KARGER

NEUROSCIENCE & BEHAVIOR

Web of Science

1.Soochow Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Suzhou, Peoples R China
2.Shanghai Jiao Tong Univ, Sch Med, Sch Publ Hlth, Shanghai, Peoples R China
3.Southern Univ Sci & Technol, Sch Publ Hlth & Emergency Management, Shenzhen, Peoples R China
4.Southern Med Univ, Sch Publ Hlth, Dept Epidemiol, Guangzhou, Peoples R China

Wan, Zhongxiao,Zhang, Xiaohui,He, Huanying,et al. Secondhand Smoke Exposure and Risk of Dementia in Nonsmokers: A Population-Based Cohort Study[J]. NEUROEPIDEMIOLOGY,2024,58(3).

Wan, Zhongxiao.,Zhang, Xiaohui.,He, Huanying.,Zhang, Yebing.,Chen, Guo-Chong.,...&Li, Fu-Rong.(2024).Secondhand Smoke Exposure and Risk of Dementia in Nonsmokers: A Population-Based Cohort Study.NEUROEPIDEMIOLOGY,58(3).

Wan, Zhongxiao,et al."Secondhand Smoke Exposure and Risk of Dementia in Nonsmokers: A Population-Based Cohort Study".NEUROEPIDEMIOLOGY 58.3(2024).