Maternal smoking, consumption of alcohol, and caffeinated beverages during pregnancy and the risk of childhood brain tumors: a meta-analysis of observational studies

Hu, Zihao1; Ye, Jianbo1; Shi, Shenbao1; Luo, Chuangcai1; Wang, Tianwei1; Liu, Yang1; Ye, Jing'an2; Sun, Xinlin1; Ke, Yiquan1; Hou, Chongxian1,3

2024-05-06

10.1186/s12889-024-18569-9

BMC PUBLIC HEALTH   影响因子和分区

1471-2458

Background We conducted this meta-analysis to investigate the potential association between maternal smoking, alcohol and caffeinated beverages consumption during pregnancy and the risk of childhood brain tumors (CBTs).Methods A thorough search was carried out on PubMed, Embase, Web of Science, Cochrane Library, and China National Knowledge Internet to identify pertinent articles. Fixed or random effects model was applied to meta-analyze the data.Results The results suggested a borderline statistically significant increased risk of CBTs associated with maternal smoking during pregnancy (OR 1.04, 95% CI 0.99-1.09). We found that passive smoking (OR 1.12, 95% CI 1.03-1.20), rather than active smoking (OR 1.00, 95% CI 0.93-1.07), led to an increased risk of CBTs. The results suggested a higher risk in 0-1 year old children (OR 1.21, 95% CI 0.94-1.56), followed by 0-4 years old children (OR 1.12, 95% CI 0.97-1.28) and 5-9 years old children (OR 1.11, 95% CI 0.95-1.29). This meta-analysis found no significant association between maternal alcohol consumption during pregnancy and CBTs risk (OR 1.00, 95% CI 0.80-1.24). An increased risk of CBTs was found to be associated with maternal consumption of caffeinated beverages (OR 1.16, 95% CI 1.07-1.26) during pregnancy, especially coffee (OR 1.18, 95% CI 1.00-1.38).Conclusions Maternal passive smoking, consumption of caffeinated beverages during pregnancy should be considered as risk factors for CBTs, especially glioma. More prospective cohort studies are warranted to provide a higher level of evidence.

Maternal smoking Maternal alcohol consumption Maternal caffeinated beverages consumption Childhood brain tumor (CBT) Glioma

SCI

英语

通讯

Public, Environmental & Occupational Health

Public, Environmental & Occupational Health

WOS:001216237800006

BMC

SOCIAL SCIENCES, GENERAL

Web of Science

1.Southern Med Univ, Engn Technol Res Ctr, Guangdong Prov Key Lab Brain Funct Repair & Regene, Natl Key Clin Specialty,Dept Neurosurg,Zhujiang Ho, Guangzhou 510282, Peoples R China
2.Southern Med Univ, Affiliated Hosp 10, Dongguan Peoples Hosp, Dept Neurosurg, Dongguan 523059, Peoples R China
3.Southern Univ Sci & Technol, Jinan Univ, Dept Neurosurg, Shenzhen Peoples Hosp,Affiliated Hosp 1,Clin Med C, Shenzhen 518020, Peoples R China

Hu, Zihao,Ye, Jianbo,Shi, Shenbao,et al. Maternal smoking, consumption of alcohol, and caffeinated beverages during pregnancy and the risk of childhood brain tumors: a meta-analysis of observational studies[J]. BMC PUBLIC HEALTH,2024,24(1).

Hu, Zihao.,Ye, Jianbo.,Shi, Shenbao.,Luo, Chuangcai.,Wang, Tianwei.,...&Hou, Chongxian.(2024).Maternal smoking, consumption of alcohol, and caffeinated beverages during pregnancy and the risk of childhood brain tumors: a meta-analysis of observational studies.BMC PUBLIC HEALTH,24(1).

Hu, Zihao,et al."Maternal smoking, consumption of alcohol, and caffeinated beverages during pregnancy and the risk of childhood brain tumors: a meta-analysis of observational studies".BMC PUBLIC HEALTH 24.1(2024).