Circadian-independent light regulation of mammalian metabolism

Rao, Feng1; Xue, Tian2

2024-06-01

10.1038/s42255-024-01051-6

NATURE METABOLISM   影响因子和分区

2522-5812

["The daily light-dark cycle is a key zeitgeber (time cue) for entraining an organism's biological clock, whereby light sensing by retinal photoreceptors, particularly intrinsically photosensitive retinal ganglion cells, stimulates the suprachiasmatic nucleus of the hypothalamus, a central pacemaker that in turn orchestrates the rhythm of peripheral metabolic activities. Non-rhythmic effects of light on metabolism have also been long known, and their transduction mechanisms are only beginning to unfold. Here, we summarize emerging evidence that, in mammals, light exposure or deprivation profoundly affects glucose homeostasis, thermogenesis and other metabolic activities in a clock-independent manner. Such light regulation could involve melanopsin-based, intrinsically photosensitive retinal ganglion cell-initiated brain circuits via the suprachiasmatic nucleus of the hypothalamus and other nuclei, or direct stimulation of opsins expressed in the hypothalamus, adipose tissue, blood vessels and skin to regulate sympathetic tone, lipolysis, glucose uptake, mitochondrial activation, thermogenesis, food intake, blood pressure and melanogenesis. These photic signalling events may coordinate with circadian-based mechanisms to maintain metabolic homeostasis, with dysregulation of this system underlying metabolic diseases caused by aberrant light exposure, such as environmental night light and shift work.","Rao and Xue discuss emerging evidence in mice and humans of circadian-independent regulation of metabolic responses by light."]

SCI

英语

第一 ; 通讯

National Natural Science Foundation of China (National Science Foundation of China)["32121002","81925009"] ; National Natural Science Foundation of China[B2301008] ; Shenzhen Medical Academy of Research and Translation[RCJC20221008092757096] ; Shenzhen Science and Technology Innovation Commission[ZDSYS20220402111000001] ; Shenzhen Science and Technology Program[2020YFA0112200] ; National Key Basic Research Program of China[YSBR-013]

Endocrinology & Metabolism

Endocrinology & Metabolism

WOS:001238167900002

NATURE PORTFOLIO

Web of Science

1.Southern Univ Sci & Technol, Sch Life Sci, Shenzhen Key Lab Biomol Assembling & Regulat, Shenzhen, Peoples R China
2.Univ Sci & Technol China, Hefei Natl Res Ctr Phys Sci Microscale, Sch Life Sci, Div Life Sci & Med,CAS Key Lab Brain Funct & Dis, Hefei, Peoples R China

Rao, Feng,Xue, Tian. Circadian-independent light regulation of mammalian metabolism[J]. NATURE METABOLISM,2024.

Rao, Feng,&Xue, Tian.(2024).Circadian-independent light regulation of mammalian metabolism.NATURE METABOLISM.

Rao, Feng,et al."Circadian-independent light regulation of mammalian metabolism".NATURE METABOLISM (2024).