南方科技大学知识苑(SUSTech KC): Hederagenin reduces AÎ²-induced oxidative damage, decreases AÎ² deposition, and promotes cell survival by the P13K/Akt signaling pathway

题名	Hederagenin reduces AÎ²-induced oxidative damage, decreases AÎ² deposition, and promotes cell survival by the P13K/Akt signaling pathway
作者	Xie, Kunpeng 1; Wang, Hao 2,3 ; Yao, Xin 1; Lv, Jialin 1; Wang, Qingyu 1; Zhao, Yu 1; Yang, Shuhan 1; Xu, Lipeng 1; Shi, Yuhua 1; Hu, Jiliang 2,3; Shan, Yaming 1,4,5
通讯作者	Hu, Jiliang; Shan, Yaming
发表日期	2024-05-01
DOI	10.1093/jleuko/qiae124
发表期刊	JOURNAL OF LEUKOCYTE BIOLOGY 影响因子和分区
ISSN	0741-5400
EISSN	1938-3673
摘要	["Alzheimer's disease (AD) is a neurodegenerative disease characterized by memory loss and cognitive impairment. beta-Amyloid (A beta) is one of the typical pathological features of AD, and its accumulation leads to neuronal death from oxidative stress. Here, we found that hederagenin (HG), a natural product, exhibits antitumor, anti-inflammatory, antidepressant, antineurodegenerative biological activities. However, whether HG has anti-A beta activity remains unclear. Based on the characteristics of HG, it is hypothesized that HG has biological activity against A beta injury. Therefore, A beta-injured SH-SY5Y cells were constructed, and the protective effect of HG against A beta injury was further evaluated using Caenorhabditis elegans. The results showed that HG increased superoxide dismutase activity, effectively reduced A beta-induced oxidative damage, and reduced apoptosis via the PI3 K/Akt signaling pathway. HG inhibited A beta deposition and delayed senescence and paralysis in the C. elegans strain, CL4176. HG showed inhibitory effects on A beta; therefore, more natural active products are expected to be applied in AD therapy.","Hederagenin reduces beta-amyloid (A beta)-induced oxidative damage and decreases A beta deposition."]
关键词	amyloid damage CL4176 hederagenin oxidative stress PI3k/Akt
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	通讯
资助项目	Department of Science and Technology of Jilin Province["20220204008YY","20210204197YY"] ; Changchun Science and Technology Bureau[21ZY15] ; Graduate Innovation Fund of Jilin University[2023CX181]
WOS研究方向	Cell Biology ; Hematology ; Immunology
WOS类目	Cell Biology ; Hematology ; Immunology
WOS记录号	WOS:001240177700001
出版者	OXFORD UNIV PRESS
ESI学科分类	IMMUNOLOGY
来源库	Web of Science
引用统计
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/788222
专题	南方科技大学第一附属医院
作者单位	1.Jilin Univ, Sch Life Sci, Natl Engn Lab AIDS Vaccine, Changchun 130012, Jilin, Peoples R China 2.Guangdong Engn Technol Res Ctr Nervous Anat & Rela, Shenzhen 518020, Guangdong, Peoples R China 3.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2,Dept Neurosurg, 1017 Dongmen North Rd, Shenzhen 518020, Guangdong, Peoples R China 4.Jilin Univ, Sch Life Sci, Key Lab Mol Enzymol & Engn, Minist Educ, Changchun 130012, Jilin, Peoples R China 5.Jilin Univ, Sch Life Sci, 2699 Qianjin St, Changchun 130012, Jilin, Peoples R China
通讯作者单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Xie, Kunpeng,Wang, Hao,Yao, Xin,et al. Hederagenin reduces AÎ²-induced oxidative damage, decreases AÎ² deposition, and promotes cell survival by the P13K/Akt signaling pathway[J]. JOURNAL OF LEUKOCYTE BIOLOGY,2024.
APA	Xie, Kunpeng.,Wang, Hao.,Yao, Xin.,Lv, Jialin.,Wang, Qingyu.,...&Shan, Yaming.(2024).Hederagenin reduces AÎ²-induced oxidative damage, decreases AÎ² deposition, and promotes cell survival by the P13K/Akt signaling pathway.JOURNAL OF LEUKOCYTE BIOLOGY.
MLA	Xie, Kunpeng,et al."Hederagenin reduces AÎ²-induced oxidative damage, decreases AÎ² deposition, and promotes cell survival by the P13K/Akt signaling pathway".JOURNAL OF LEUKOCYTE BIOLOGY (2024).