南方科技大学知识苑(SUSTech KC): Predictive Role of Platelet and Inflammation Markers for Severe COVID-19 by Propensity Score Matching

题名	Predictive Role of Platelet and Inflammation Markers for Severe COVID-19 by Propensity Score Matching
作者	Liu, Yan 1 ; Huang, Hua 2; Zheng, Jiawei 1; Liu, Zhichao 1; Peng, Denggao 1
通讯作者	Peng, Denggao
发表日期	2024
DOI	10.7754/Clin.Lab.2023.231027
发表期刊	CLINICAL LABORATORY 影响因子和分区
ISSN	1433-6510
卷号	70 期号:4
摘要	Background: This study aims to ascertain the predictive value of platelet and inflammation markers in severe cases of COVID-19. Methods: A retrospective real-world cohort study was conducted using propensity score matching (PSM). Patients were classified into severe and non-severe COVID-19 groups based on the severity of the disease, and the correlation between severe COVID-19 and laboratory parameters at admission was analyzed. Results: The study included 397 adult patients, comprising 212 (53%) males and 185 (47%) females. Among these, 309 were non-severe and 88 were severe cases. The severe group had a higher median age than the non-severe group (60 vs. 42 years, p < 0.001). Independent risk factors for severe COVID-19 included age, diabetes comor6), and the ratio of arterial oxygen partial pressure (PaO2) to the fraction of inspired oxygen (FiO(2)) (P/F ratio). After one-to-one PSM, adjusted for age, diabetes comorbidities, fever, and respiratory symptoms, significant differences in laboratory parameters at admission were observed. Compared to the non-severe group (n = 71), in the severe group (n = 71), elevated levels of hsCRP (median: 27.1 mg/L vs. 14.6 mg/L, p = 0.005) and IL-6 (median: 16.2 pg/mL vs. 15.3 pg/mL, p = 0.005) were observed, while platelet count (164 +/- 36 x 10(9) vs. 180 +/- 50 x 10(9), p = 0.02) and P/F ratio (median: 351 vs. 397, p = 0.001) were reduced. Conclusions: Elevated levels of hsCRP and IL-6, along with reduced platelet count and P/F ratio at admission, were significantly associated with severe COVID-19 and may serve as predictive indicators.
关键词	Platelet inflammation markers severe cases of COVID-19 propensity score matching (PSM)
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
WOS研究方向	Medical Laboratory Technology
WOS类目	Medical Laboratory Technology
WOS记录号	WOS:001226387500004
出版者	CLIN LAB PUBL
来源库	Web of Science
引用统计
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/788263
专题	南方科技大学第二附属医院南方科技大学第一附属医院
作者单位	1.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Hosp 2, Dept Emergency Med, 29 Bulan Rd, Shenzhen 518112, Peoples R China 2.Southern Univ Sci & Technol, Peoples Hosp Shenzhen 3, Natl Clin Res Ctr Infect Dis, Dept Radiol,Affiliated Hosp 2, Shenzhen, Peoples R China
第一作者单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
通讯作者单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
第一作者的第一单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Liu, Yan,Huang, Hua,Zheng, Jiawei,et al. Predictive Role of Platelet and Inflammation Markers for Severe COVID-19 by Propensity Score Matching[J]. CLINICAL LABORATORY,2024,70(4).
APA	Liu, Yan,Huang, Hua,Zheng, Jiawei,Liu, Zhichao,&Peng, Denggao.(2024).Predictive Role of Platelet and Inflammation Markers for Severe COVID-19 by Propensity Score Matching.CLINICAL LABORATORY,70(4).
MLA	Liu, Yan,et al."Predictive Role of Platelet and Inflammation Markers for Severe COVID-19 by Propensity Score Matching".CLINICAL LABORATORY 70.4(2024).